PMID: 25749032Mar 10, 2015Paper

miR-27a and miR-27a* contribute to metastatic properties of osteosarcoma cells

Oncotarget
Zaidoun SalahRami I Aqeilan

Abstract

Osteosarcoma (OS) is the most common primary malignant bone tumor in adolescents and young adults. The essential mechanisms underlying osteosarcomagenesis and progression continue to be obscure. MicroRNAs (miRNAs) have far-reaching effects on the cellular biology of development and cancer. We recently reported that unique miRNA signatures associate with the pathogenesis and progression of OS. Of particular interest, we found that higher expression of miR-27a is associated with clinical metastatic disease. We report here that overexpression of miR-27a/miR-27a*, a microRNA pair derived from a single precursor, promotes pulmonary OS metastases formation. By contrast, sequestering miR-27a/miR-27a* by sponge technology suppressed OS cells invasion and metastases formation. miR-27a/miR-27a* directly repressed CBFA2T3 expression among other target genes. We demonstrated that CBFA2T3 is downregulated in majority of OS samples and its over expression significantly attenuated OS metastatic process mediated by miR-27a/miR-27a* underscoring CBFA2T3 functions as a tumor suppressor in OS. These findings establish that miR-27a/miR-27a* pair plays a significant role in OS metastasis and proposes it as a potential diagnostic and therapeutic tar...Continue Reading

References

Apr 14, 2000·Clinical & Experimental Metastasis·S F JiaE S Kleinerman
Oct 8, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Angela L AsirvathamDaniel W Carr
Apr 9, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Fumikazu SutoHajime Fujisawa
Oct 15, 2005·Development·Tingting Du, Phillip D Zamore
Jul 25, 2006·Cancer Treatment Reviews·Alessandra LonghiGaetano Bacci
Oct 25, 2006·Nature Reviews. Cancer·George A Calin, Carlo M Croce
Aug 19, 2007·Nature Methods·Margaret S EbertPhillip A Sharp
May 6, 2008·The Journal of Biological Chemistry·Raman KumarDavid F Callen
Jul 29, 2008·Cancer Genetics and Cytogenetics·Etienne De BraekeleerMarc De Braekeleer
Oct 28, 2008·BMC Molecular Biology·Stefano RossettiAndre T Hoogeveen
Mar 6, 2009·Nature Reviews. Cancer·Milena S NicolosoGeorge A Calin
Sep 19, 2009·Nature Reviews. Genetics·Carlo M Croce
Nov 3, 2009·Journal of Virological Methods·Irit ReichensteinYonat Shemer Avni
Dec 8, 2009·Journal of Cellular and Molecular Medicine·Stefano RossettiNicoletta Sacchi
Mar 10, 2010·Cancer Treatment and Research·Norman Jaffe
Jun 23, 2010·Proceedings of the National Academy of Sciences of the United States of America·Urmila SantanamYuri Pekarsky
Dec 24, 2010·RNA·Jr-Shiuan YangEric C Lai
Jun 2, 2011·Blood·Florian KuchenbauerR Keith Humphries
Feb 22, 2012·Cancer Research·Kevin B JonesRami I Aqeilan
Oct 30, 2012·Molecular Oncology·Martin D Jansson, Anders H Lund
Jun 4, 2013·Nature Cell Biology·Nora Pencheva, Sohail F Tavazoie
Jun 27, 2013·Nature Reviews. Molecular Cell Biology·Stefan L Ameres, Phillip D Zamore
Aug 22, 2013·Oncotarget·Xiaoli WuStephen Y Lai
Dec 3, 2013·Journal of Experimental & Clinical Cancer Research : CR·Zhenglong WuYujiang Guo
Feb 22, 2014·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Weibo PanZhaoming Ye
Jul 17, 2014·Nature Reviews. Molecular Cell Biology·Minju Ha, V Narry Kim
Oct 9, 2014·Frontiers in Genetics·Gabriel A Cipolla

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Citations

Sep 18, 2015·Frontiers in Pediatrics·Valerie B SampsonE Anders Kolb
Jan 21, 2016·Oncotarget·Qing-Ming ShiXi-Gao Cheng
Apr 25, 2019·International Journal of Cancer. Journal International Du Cancer·Vadim V MaximovRami I Aqeilan
Jan 1, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Zheng LiJianxiong Shen
Dec 31, 2016·International Journal of Molecular Medicine·Hua ChenPeifu Tang
Apr 30, 2017·Oncology Letters·Pengzhou GaiLei Jiang
Jan 5, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Xiao-Xu WangGuang-Hua Tan
Aug 7, 2018·Investigational New Drugs·Chongchong WangLi Cheng
Apr 14, 2016·Future Oncology·Vadim V Maximov, Rami I Aqeilan
Mar 14, 2016·Cancer Metastasis Reviews·Jörg HaierRichard Hummel
Oct 21, 2015·Oncotarget·Katarzyna KlonowskaPiotr Kozlowski
Apr 9, 2016·International Journal of Molecular Sciences·Atik Badshah ShaikhGe Zhang
Jul 18, 2017·Molecular Medicine Reports·Lankai YiZhiliang Tang
Dec 30, 2017·Oncotarget·Dawei XuZhiming Cui
Aug 31, 2016·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Xiufen ZhangLihua Li
Apr 26, 2019·Journal of Gastrointestinal Cancer·Mohaddese MaghsudluTaghi Amiriani
Apr 6, 2019·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·G M VieraM S Brassesco
Sep 1, 2018·Cancer Metastasis Reviews·Dylan C DeanZhenfeng Duan
Aug 21, 2021·Oxidative Medicine and Cellular Longevity·Yandong BaoDalin Jia

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