MiR-27a targets DKK2 and SFRP1 to promote reosseointegration in the regenerative treatment of peri-implantitis

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
Xiaolin WuHui Huang

Abstract

In the inflamed microenvironment of peri-implantitis, limited osteogenesis on the implant surface impedes well-established reosseointegration using current clinical therapies. MicroRNAs (miRNAs) function as potent molecular managers that may simultaneously regulate multiple endogenous processes such as inflammation and osteogenesis. The delivery of miRNAs may provide a way to effectively treat some diseases. In this study, we showed that miR-27a was differentially downregulated in samples from a canine peri-implantitis model. We found that overexpressing miR-27a positively regulated osteogenesis-angiogenesis coupling by ameliorating the TNF-α inhibition of bone formation in vitro. Mechanistically, we identified Dickkopf2 (DKK2) and secreted frizzled related protein 1 (SFRP1) as two essential direct miR-27a targets that were osteogenic and angiogenic. Furthermore, we constructed a miR-27a-enhanced delivery system to repair the bone defect around implants in a canine peri-implantitis model. The results demonstrated that the miR-27a-treated group could optimize new bone formation and reosseointegration in vivo. Our assay provides evidence that this strategy exerts therapeutic effects on peri-implantitis, suggesting that it represe...Continue Reading

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Citations

Jun 9, 2019·Calcified Tissue International·Sepanta HosseinpourQingsong Ye
Jun 14, 2020·International Journal of Molecular Sciences·Farah Asa'adLena Larsson
Sep 17, 2020·Histochemistry and Cell Biology·Elizabeth A LawrenceEmma J Blain
Nov 9, 2019·European Journal of Oral Sciences·Farah Asa'adLena Larsson
Dec 10, 2020·Journal of Periodontal Research·Yun YuanHui Huang
Sep 6, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Danqi YaoXiao Zhu

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