MiR-299-3p functions as a tumor suppressor via targeting Sirtuin 5 in hepatocellular carcinoma

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Shan DangShuixiang He

Abstract

Hepatocellular carcinoma(HCC) is one of the most common cancers in the world, with the characteristics of high morbidity and mortality. Though the levels of diagnosis and treatment of HCC have been largely improved recently, the prognosis of these patients remains unacceptable. Thus, it is urgent for us to discover the exact mechanisms and determine some new biomarkers for HCC. Previous studies revealed that microRNAs (miRNAs) played a critical role in the occurrence and progression of HCC. And miR-299-3p has been reported to be closely related to the progression of colon carcinoma, lung cancer and clear cell renal cell carcinoma and so on. However, the exact expression and functions of miR-299-3p in HCC are still uncovered. Here, we reported for the first time that miR-299-3p was downregulated in HCC. Clinically, statistical analysis showed that miR-299-3p expression was significantly associated with tumor size (P = 0.007), venous infiltration (P = 0.028), Edmondson-Steiner grading (P = 0.042) and TNM stage (P = 0.012). In addition, HCC patients with lower miR-299-3p expression had worse 3-year overall survival and disease-free survival (P = 0.0012, P = 0.0002). Functionally, Transwell assays, Wound healing assay, MTT assay an...Continue Reading

References

Jun 28, 2013·World Journal of Hepatology·Manal A Hamed, Sanaa A Ali
Jul 30, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Weidong LuMin Zhang
Dec 25, 2015·Oncotarget·Carla BartoschCarmen Jerónimo
May 11, 2016·Free Radical Biology & Medicine·Brenna OsborneNigel Turner
Dec 29, 2016·Advances in Clinical and Experimental Medicine : Official Organ Wroclaw Medical University·Jie XuZuo-Jin Liu
Jul 15, 2017·Antioxidants & Redox Signaling·Lauren R Bringman-RodenbargerDavid B Lombard
Jul 26, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Jia-Yong WangYong Dai
Dec 16, 2017·The Biochemical Journal·Ondrej SlabyOndrej Sedlacek
Jan 3, 2018·Frontiers in Bioscience (Landmark Edition)·Kurt SartoriusJulia Makarova
Jan 9, 2018·World Journal of Gastroenterology : WJG·Brandon J PerumpailAijaz Ahmed
Jan 20, 2018·Cancer Control : Journal of the Moffitt Cancer Center·Kun JiangBarbara A Centeno
Jan 23, 2018·Cancer Control : Journal of the Moffitt Cancer Center·Kun Jiang, Barbara A Centeno

❮ Previous
Next ❯

Citations

Oct 29, 2019·Current Gene Therapy·Mahmoud ElhefnawiBangly Soliman
Jul 7, 2020·Cell Biochemistry and Function·Jia-Hui GuoFeng-Hou Gao
Jul 2, 2019·Molecular Medicine Reports·Xiangjun ZhouZhenghui Ge
Dec 11, 2019·Cancers·Erhu ZhaoHongjuan Cui
Sep 4, 2020·Scientific Reports·Srinivasulu Yerukala Sathipati, Shinn-Ying Ho
Sep 11, 2019·Technology in Cancer Research & Treatment·Yaoxiang XuJian Sun
Nov 10, 2020·Cell Cycle·Hedyieh KarbasforooshanGholamreza Karimi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Migration in Cancer and Metastasis

Migration of cancer cells into surrounding tissue and the vasculature is an initial step in tumor metastasis. Discover the latest research on cell migration in cancer and metastasis here.

Carcinoma, Hepatocellular

Hepatocellular Carcinoma is a malignant cancer in liver epithelial cells. Discover the latest research on Hepatocellular Carcinoma here.

Adenocarcinoma, Clear Cell

Clear Cell Adenocarcinoma is a tumor that arises in the female genital tract and is characterized by cells that appear clear under the microscope. Discover the latest research here.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.