Abstract
Hepatocellular carcinoma(HCC) is one of the most common cancers in the world, with the characteristics of high morbidity and mortality. Though the levels of diagnosis and treatment of HCC have been largely improved recently, the prognosis of these patients remains unacceptable. Thus, it is urgent for us to discover the exact mechanisms and determine some new biomarkers for HCC. Previous studies revealed that microRNAs (miRNAs) played a critical role in the occurrence and progression of HCC. And miR-299-3p has been reported to be closely related to the progression of colon carcinoma, lung cancer and clear cell renal cell carcinoma and so on. However, the exact expression and functions of miR-299-3p in HCC are still uncovered. Here, we reported for the first time that miR-299-3p was downregulated in HCC. Clinically, statistical analysis showed that miR-299-3p expression was significantly associated with tumor size (P = 0.007), venous infiltration (P = 0.028), Edmondson-Steiner grading (P = 0.042) and TNM stage (P = 0.012). In addition, HCC patients with lower miR-299-3p expression had worse 3-year overall survival and disease-free survival (P = 0.0012, P = 0.0002). Functionally, Transwell assays, Wound healing assay, MTT assay an...Continue Reading
References
Feb 6, 2013·Oncology Reports·Xin LiuXiaodong Liu
Jun 28, 2013·World Journal of Hepatology·Manal A Hamed, Sanaa A Ali
Apr 30, 2014·BMC Cancer·Jia-Xing WangShuang-Jian Qiu
Jul 30, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Weidong LuMin Zhang
May 6, 2015·PloS One·Haowei HeJingping Ge
Dec 25, 2015·Oncotarget·Carla BartoschCarmen Jerónimo
May 11, 2016·Free Radical Biology & Medicine·Brenna OsborneNigel Turner
Dec 29, 2016·Advances in Clinical and Experimental Medicine : Official Organ Wroclaw Medical University·Jie XuZuo-Jin Liu
Dec 31, 2016·Oncotarget·Ye XiangyunLu Shun
May 19, 2017·Cell Death & Disease·Likun ZhuangLiqun Wu
Jul 15, 2017·Antioxidants & Redox Signaling·Lauren R Bringman-RodenbargerDavid B Lombard
Jul 26, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Jia-Yong WangYong Dai
Dec 16, 2017·The Biochemical Journal·Ondrej SlabyOndrej Sedlacek
Jan 3, 2018·Frontiers in Bioscience (Landmark Edition)·Kurt SartoriusJulia Makarova
Jan 9, 2018·World Journal of Gastroenterology : WJG·Brandon J PerumpailAijaz Ahmed
Jan 20, 2018·Cancer Control : Journal of the Moffitt Cancer Center·Kun JiangBarbara A Centeno
Jan 23, 2018·Cancer Control : Journal of the Moffitt Cancer Center·Kun Jiang, Barbara A Centeno
Feb 9, 2018·Nature Communications·Yun-Qian WangJing-Yuan Fang
Mar 2, 2018·EMBO Reports·Xiu-Fei ChenDan Ye
Citations
May 8, 2019·Cells·Tommaso MelloAndrea Galli
Oct 29, 2019·Current Gene Therapy·Mahmoud ElhefnawiBangly Soliman
Oct 28, 2019·Digestive Diseases and Sciences·Ke Xu, Lianfeng Zhang
Jul 7, 2020·Cell Biochemistry and Function·Jia-Hui GuoFeng-Hou Gao
Jul 2, 2019·Molecular Medicine Reports·Xiangjun ZhouZhenghui Ge
Jul 1, 2020·Journal of Cellular and Molecular Medicine·Bowen YaoQingguang Liu
Mar 22, 2020·Scientific Reports·Kavya GanapathyRatna Chakrabarti
Apr 7, 2020·Briefings in Bioinformatics·Song ZhangFeng Zhu
Dec 11, 2019·Cancers·Erhu ZhaoHongjuan Cui
Sep 4, 2020·Scientific Reports·Srinivasulu Yerukala Sathipati, Shinn-Ying Ho
Sep 11, 2019·Technology in Cancer Research & Treatment·Yaoxiang XuJian Sun
Jul 2, 2020·Molecular and Cellular Biochemistry·Shu-Juan Tang, Jing-Bo Yang
Oct 28, 2020·Journal of Cellular and Molecular Medicine·Qiang Yao, Ting Chen
Nov 10, 2020·Cell Cycle·Hedyieh KarbasforooshanGholamreza Karimi
Dec 30, 2020·Bioengineered·Derong Yin, Xiaohong Lu
Nov 17, 2020·OncoTargets and Therapy·Xi YangBugao Guan
Feb 4, 2021·Journal of Orthopaedic Surgery and Research·Beibei ZuJunxia Yang
Apr 2, 2021·Personalized Medicine·Can ChenJunhua Lu
Feb 4, 2021·Aging·Jinlan GuoMingliang Dong
Apr 6, 2021·Open Life Sciences·Zhenfen WangGuohao Cai
Apr 10, 2021·Free Radical Biology & Medicine·Y LiJ-Y Peng
Apr 1, 2021·Journal of Biochemistry·Baiyin MuHong Yang
Aug 7, 2021·Biomedicines·Elan C McCarthy, Róisín M Dwyer
Aug 1, 2021·Cell Biology and Toxicology·Qinhua LiuRuixiang Xia
Oct 1, 2021·Oncology Letters·Ming AnTonghua Chen