miR-302 Attenuates Amyloid-β-Induced Neurotoxicity through Activation of Akt Signaling

Journal of Alzheimer's Disease : JAD
Hsin-Hua LiChih-Li Lin

Abstract

Deficiency of insulin signaling has been linked to diabetes and ageing-related neurodegenerative diseases such as Alzheimer's disease (AD). In this regard, brains exhibit defective insulin receptor substrate-1 (IRS-1) and hence result in alteration of insulin signaling in progression of AD, the most common cause of dementia. Consequently, dysregulation of insulin signaling plays an important role in amyloid-β (Aβ)-induced neurotoxicity. As the derivation of induced pluripotent stem cells (iPSC) involves cell reprogramming, it may provide a means for regaining the control of ageing-associated dysfunction and neurodegeneration via affecting insulin-related signaling. To this, we found that an embryonic stem cell (ESC)-specific microRNA, miR-302, silences phosphatase and tensin homolog (PTEN) to activate Akt signaling, which subsequently stimulates nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) elevation and hence inhibits Aβ-induced neurotoxicity. miR-302 is predominantly expressed in iPSCs and is known to regulate several important biological processes of anti-oxidative stress, anti-apoptosis, and anti-aging through activating Akt signaling. In addition, we also found that miR-302-mediated Akt signali...Continue Reading

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Citations

Feb 23, 2019·Cellular and Molecular Neurobiology·Chongyang TangZhiguo Lin
Mar 19, 2019·Frontiers in Genetics·Mengli WangBeisha Tang
Aug 28, 2018·Archives of Physiology and Biochemistry·Hemat El-Sayed El-HoranyDuaa Samir Helal
Nov 7, 2019·International Journal of Molecular Sciences·Mirza Muhammad Fahd QadirRicardo Luis Pastori
Jun 20, 2020·Annals of Neurology·Zoe ArvanitakisSteven E Arnold
Dec 18, 2019·In Vitro Cellular & Developmental Biology. Animal·Lianhua JinJinhua Piao
Sep 26, 2020·Frontiers in Molecular Neuroscience·Wei WeiHao Li
Aug 14, 2020·Acta Biochimica Et Biophysica Sinica·Menghuan GuoHong Zhang
Mar 21, 2018·Neural Regeneration Research·Hsin-Hua LiChien-Ning Huang
Feb 20, 2019·Frontiers in Pharmacology·Andrea Rodrigues VasconcelosCarolina Demarchi Munhoz
Dec 31, 2020·Journal of Clinical Medicine·Joanna Jarosz-PopekCeren Eyileten
Aug 28, 2021·International Journal of Molecular Sciences·Ching-Chi ChangChih-Li Lin

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