MiR-30a: A Novel Biomarker and Potential Therapeutic Target for Cancer

Journal of Oncology
Lin-Hong JiangJinhai Tang

Abstract

MicroRNAs (miRNAs) are small, highly conserved noncoding RNAs molecules, consisting of 18-25 nucleotides that regulate gene expression by binding to complementary binding sites within the 3'untranslated region (3'UTR) of target mRNAs. MiRNAs have been involved in regulating gene expression and diverse physiological and pathological processes. Several studies have reported that miR-30a, situated on chromosome 6q.13, is produced by an intronic transcriptional unit. Moreover, miR-30a has demonstrated its role in biological processes, including inhibiting proliferation and metastasis in many tumors, autophagy in chronic myelogenous leukemia, and regulating TGF-b1-induced epithelial-mesenchymal transition. However, based on the pathogenetic relationship between miR-30a and cancer in tumorigenesis, we believe that miR-30a may serve as tumor promising biomarker. Moreover, it would offer a therapeutic target for the treatment of cancer.

References

Mar 14, 2000·Critical Reviews in Oncology/hematology·T Tokino, Y Nakamura
Mar 6, 2004·Cancer Metastasis Reviews·Stanley Zucker, Jeffrey Vacirca
Aug 26, 2004·Molecular Cell·Oronza A BotrugnoKristina Schoonjans
Oct 18, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Meenali M ChitnisValentine M Macaulay
May 14, 2009·Nature Reviews. Molecular Cell Biology·Daniela Rotin, Sharad Kumar
Jul 22, 2009·Developmental Cell·Bryan T MacDonaldXi He
Jun 3, 2011·International Journal of Cancer. Journal International Du Cancer·Regalla KumarswamyHeike Allgayer
Jun 28, 2011·BMC Systems Biology·Chien-Wei TsengHsueh-Fen Juan
Jan 31, 2012·Carcinogenesis·Alexander BaraniskinStephan A Hahn
Mar 15, 2012·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Zhendong ShiChunsheng Kang
Mar 1, 2013·BMC Genomics·Maria OuzounovaHector Hernandez-Vargas
Mar 15, 2013·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Ming ZhongZhiyong Wu
Jun 1, 2013·International Journal of Molecular Sciences·Chia-Hsien LeeHsueh-Fen Juan
Jun 27, 2013·British Journal of Cancer·S WachB Wullich
Oct 5, 2013·Cancer Treatment Reviews·Paraskevi MalliniAnnette Meeson
Dec 3, 2013·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·W WangS Zheng
Jan 23, 2014·Journal of Cellular and Molecular Medicine·Zhifang LiuJihui Jia
Feb 11, 2014·Biochemical and Biophysical Research Communications·Jing FuZhaohui Lv
Mar 13, 2014·Trends in Cell Biology·Daniele CanzioGeeta J Narlikar
Sep 30, 2014·Biochemical and Biophysical Research Communications·Quan HuangJianru Xiao
Nov 25, 2014·Molecular Cancer Therapeutics·George E DuranBranimir I Sikic
Jan 13, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Ning LuJinsong Li
Jan 13, 2015·Systems Biology in Reproductive Medicine·Ganapathy Narmadha, Suresh Yenugu
Jan 15, 2015·Molecular and Cellular Biology·Qian ZhangXishan Wang
Jan 27, 2015·Oncology Letters·Tairen WangShengjian Tang
Feb 6, 2015·CA: a Cancer Journal for Clinicians·Lindsey A TorreAhmedin Jemal
Feb 19, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·He-da ZhangJin-hai Tang
Feb 26, 2015·Biochemical and Biophysical Research Communications·Bing ZhengYuxi Shan

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Citations

Feb 7, 2020·The Journal of Pharmacy and Pharmacology·Vahab Alamdari-PalangiHadi Karami
Apr 17, 2020·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Siamak SalehiVaruna R Aluvihare
Jan 25, 2020·Cancer Science·Yasutaka YamadaNaohiko Seki
Apr 3, 2020·Journal of Biomedical Science·Shine-Gwo ShiahJang-Yang Chang
Sep 10, 2020·International Journal of Molecular Sciences·Hiroki ShimomuraNaohiko Seki
Mar 1, 2020·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Jimin MinHan-Kwang Yang
Sep 15, 2019·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Fabian PlachelAndreas Traweger
Dec 24, 2019·Frontiers in Genetics·Beatriz Andrea Otálora-OtáloraAdriana Rojas
Oct 8, 2020·International Journal of Molecular Sciences·Chun-Chia ChengChun-Chao Chang
Jun 3, 2021·International Journal of Molecular Sciences·Szu-Yi LiuYin-Chou Hsu
Jun 3, 2021·International Journal of Molecular Sciences·Ann-Kathrin EichelmannDamian J Hussey
Aug 3, 2021·Experimental and Therapeutic Medicine·Liang PanJianming Guo

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Methods Mentioned

BETA
nuclear translocation
ChIP

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