Abstract
miR-30c has been acknowledged as a tumor suppressor in various human cancers, such as ovarian cancer, gastric cancer, and prostate cancer. However, the role of miR-30c in glioblastoma (GBM) needs to be investigated. In our study, we found that the expression of miR-30c was significantly downregulated in GBM tissues and cell lines. We found that overexpression of miR-30c inhibited cellular proliferation of GBM cells in vitro and in vivo. More GBM cells were arrested in the G0 phase after miR-30c overexpression. Moreover, we showed that miR-30c overexpression suppressed the migration and invasion of GBM cells. Mechanistically, we found that SOX9 was a direct target of miR-30c in GBM cells. Overexpression of miR-30c inhibited the mRNA and protein levels of SOX9 in GBM cells. Moreover, there was a negative correlation between the expression of miR-30c and SOX9 in GBM tissues. Finally, we showed that restoration of SOX9 in GBM cells reversed the proliferation, migration, and invasion of GBM cells transfected with miR-30c mimic. Collectively, our results demonstrated that miR-30c suppressed the proliferation, migration, and invasion of GBM cells via targeting SOX9.
References
May 23, 2007·Archives of Pathology & Laboratory Medicine·C Ryan Miller, Arie Perry
Oct 24, 2008·The New England Journal of Medicine·Michael A Meyer
May 7, 2010·CA: a Cancer Journal for Clinicians·Erwin G Van MeirJeffrey J Olson
Jun 10, 2011·Current Oncology·J C EasawUNKNOWN Canadian Glioblastoma Recommendations Committee
Jul 3, 2013·Neuro-oncology·Sandhya B RaniAnjali S Shiras
Aug 15, 2014·Molecular Medicine Reports·Zhaopeng ZhongYijiang Chen
Mar 17, 2015·Biochemical and Biophysical Research Communications·Koji HiraokaTetsu Akiyama
Apr 9, 2016·Oncoimmunology·David C BinderDerek A Wainwright
Apr 25, 2016·Journal of Neuro-oncology·Andrew W SmithA Gabriella Wernicke
Dec 3, 2016·Oncotarget·Nan LiuYanyang Tu
Jul 6, 2017·Molecular Medicine Reports·Ya-Qiang HuangShao-Peng Qiu
Jul 8, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Jing-Mei CaoKun-Ming Huang
Jul 12, 2017·Oncology Letters·Jun ZhangGuowei Shi
Jul 21, 2017·Cellular & Molecular Biology Letters·Mingxi ZengChangming Kang
Jul 21, 2017·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Zhi-Gang YangYing-Xin Guo
Jul 21, 2017·PloS One·Po-Len LiuInn-Wen Chong
Jul 22, 2017·Molecular Medicine Reports·Jian-Jun QuDe-Zhen Zhou
Jul 25, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Kun ZhouGang Sun
Jul 25, 2017·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Yiran SiYi Ba
Jul 26, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Jia-Yong WangYong Dai
Sep 14, 2017·Journal of Cancer Research and Therapeutics·Xia WangDi Wang
Sep 19, 2017·International Journal of Cancer. Journal International Du Cancer·Yang FanXu Zhang
Sep 21, 2017·Oncology Letters·Aijun YangCuifang Hao
Sep 21, 2017·Oncology Letters·Wenhui QiaoLei Yang
Nov 10, 2017·PloS One·Georg RichtigMartin Pichler
Dec 17, 2017·Oncotarget·Shuai ZhangYan Yu
Citations
Aug 1, 2019·Cell Proliferation·Xueping XieXiaoxiao Cai
Nov 13, 2019·Human Cell·Bin LiMingsheng Chen
May 12, 2020·The Kaohsiung Journal of Medical Sciences·Chan LiuXian-Zhe Huang
Sep 22, 2019·Aging·Yongchun ZhouYunchao Huang
Sep 19, 2020·Cancer Control : Journal of the Moffitt Cancer Center·Burt P Kotler, Joel S Brown
Jan 21, 2021·Stem Cell Research & Therapy·Qing ZhangZhoubin Li
Oct 31, 2020·Biotechnology Letters·Yanmei ZhongBing Jiang
Apr 4, 2021·Brain Research·Huan Zhang, Wei Xu
May 7, 2021·International Journal of Biological Macromolecules·Milad AshrafizadehMichael R Hamblin
May 29, 2021·Life Sciences·Mohamad MahjoorSamaneh Khorrami
Aug 21, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Milad AshrafizadehMasoud Najafi
Sep 11, 2021·Bioengineered·Shangshang HuYu Gao