miR-323a regulates ERBB4 and is involved in depression.

Molecular Psychiatry
Laura M FioriGustavo Turecki

Abstract

Major depressive disorder (MDD) is a complex and debilitating illness whose etiology remains unclear. Small RNA molecules, such as micro RNAs (miRNAs) have been implicated in MDD, where they display differential expression in the brain and the periphery. In this study, we quantified miRNA expression by small RNA sequencing in the anterior cingulate cortex and habenula of individuals with MDD and psychiatrically-healthy controls. Thirty-two miRNAs showed significantly correlated expression between the two regions (False Discovery Rate < 0.05), of which four, miR-204-5p, miR-320b, miR-323a-3p, and miR-331-3p, displayed upregulated expression in MDD. We assessed the expression of predicted target genes of differentially expressed miRNAs in the brain, and found that the expression of erb-b2 receptor tyrosine kinase 4 (ERBB4), a gene encoding a neuregulin receptor, was downregulated in both regions, and was influenced by miR-323a-3p in vitro. Finally, we assessed the effects of manipulating miRNA expression in the mouse ACC on anxiety- and depressive-like behaviors. Mice in which miR-323-3p was overexpressed or knocked-down displayed increased and decreased emotionality, respectively. Additionally, these mice displayed significantly...Continue Reading

References

Sep 24, 2004·RNA·Marc RehmsmeierRobert Giegerich
Aug 19, 2007·Nature Methods·Margaret S EbertPhillip A Sharp
Feb 5, 2008·Schizophrenia Research·Victor Z ChongCynthia Shannon Weickert
Jul 9, 2009·The Journal of Biological Chemistry·Michael R EpisPeter J Leedman
May 4, 2010·Journal of Neuroscience Methods·Yong-Hong YiYue-Sheng Long
Jun 4, 2011·PloS One·Fernando S GoesJames B Potash
Jul 25, 2012·Cellular and Molecular Life Sciences : CMLS·Leonidas BenetatosEvangelos Briasoulis
Sep 25, 2012·Aging·Kira S SheinermanSamuil R Umansky
Oct 10, 2012·Bioinformatics·Chong-Jian ChenEmmanuel Barillot
Oct 22, 2013·Journal of Neuro-oncology·Michael R EpisPeter J Leedman
Nov 28, 2013·Nucleic Acids Research·Ana Kozomara, Sam Griffiths-Jones
Aug 1, 2014·Journal of Molecular Neuroscience : MN·Anita KretschmannAlexander Pfeifer
Oct 14, 2014·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Lin-Lin BiTian-Ming Gao
Oct 14, 2014·Frontiers in Pediatrics·Cherry IgnacioFrank A Middleton
Dec 18, 2014·Genome Biology·Michael I LoveSimon Anders
Mar 21, 2015·Nature Reviews. Neuroscience·Orna Issler, Alon Chen
Aug 1, 2015·Nature Methods·Harsh Dweep, Norbert Gretz
Jan 23, 2016·Aging Cell·Chand Parvez Danka MohammedKeetae Kim
Feb 28, 2016·Nucleic Acids Research·Nicole LudwigAndreas Keller
Jul 29, 2016·Journal of Psychiatric Research·Joshua A AzevedoRobert C Thompson
Aug 26, 2016·World Journal of Gastrointestinal Oncology·Toshihiro TadanoTooru Shimosegawa
Mar 24, 2017·Stem Cell Reports·Meritxell Pons-EspinalDavide De Pietri Tonelli

❮ Previous
Next ❯

Citations

May 5, 2021·Translational Psychiatry·Helena Caria Martins, Gerhard Schratt
Aug 23, 2021·Translational Psychiatry·Laura M FioriGustavo Turecki

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.