MiR-330 inhibits IL-22-induced keratinocyte proliferation through targeting CTNNB1

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Hui ShenZhibo Yang

Abstract

Psoriasis is a common chronic inflammatory skin disease which is characterized by hyperproliferation and aberrant differentiation of keratinocytes; however the exact pathogenesis is largely unknown. Interleukin-22 (IL-22) has demonstrated its vital role in T cell-mediated immune response by interacting with keratinocytes in the pathogenesis of psoriasis. The microRNAs (miRNAs) are a class of small non-coding RNA molecules that play important roles in cellular processes by regulating gene expression at the post-transcriptional level. MiR-330 has been reported to inhibit the proliferation and migration of mouse keratinocytes. In the present study, we indicated that miR-330 expression in lesion tissue of psoriasis patients was specifically down-regulated, and could inhibit IL-22-induced proliferation of HaCaT and HKC cell. Wnt/β-catenin pathway plays an essential role in the pathogenesis of psoriasis. By direct targeting CTNNB1, miR-330 could significantly downregulate IL-22-induced CTNNB1 expression. In addition, we found that the downstream targets of β-catenin, CyclinD1 and Axin2, could be affected by miR-330; miR-330 could suppress CyclinD1 protein expression and rescue Axin2 protein expression. Taken together, we indicated mi...Continue Reading

Citations

Sep 17, 2018·Cell Communication and Signaling : CCS·Yan WuJulia Li Zhong
Aug 18, 2020·Drug Design, Development and Therapy·Qi HeJiawen Li
Aug 19, 2020·International Journal of Molecular Sciences·Ai-Young Lee
Mar 24, 2021·Experimental Dermatology·Chang ZengJohann E Gudjonsson
Jul 31, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Meijunzi LuoChang Wang

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