miR-335 directly, while miR-34a indirectly modulate survivin expression and regulate growth, apoptosis, and invasion of gastric cancer cells

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Bairen YangGuoxin Li

Abstract

miR-335 and miR-34a are two microRNAs (miRNAs) usually downregulated in gastric cancer (GC). But, their exact regulative roles were not fully elucidated. In this study, we studied the association between miR-335 and/or miR-34a expression and overall survival of GC patients and explored the regulative role of miR-335 and -34a over survivin expression and GC cell growth and invasion. Fifty patients with GC were regularly followed up from 2011 to 2015. miRNA microarray was used to examine the expression trend of miRNAs in eight tumor tissue samples and adjacent normal tissue samples. The possible binding site between miR-335 and survivin messenger RNA (mRNA) was predicted using online database and verified using qRT-PCR, Western blot, and dual luciferase assay. The regulative role of miR-335 and miR-34a over GC cell growth, apoptosis, and invasion was studied using Cell Counting Kit-8 (CCK-8) assay, flow cytometry, and transwell assay, respectively. Among the GC patients, low miR-335 or miR-34a expression is associated with higher clinical stage and lymph node metastasis. Patients with low miR-335 or miR-34a had poor overall survival, while those with combined low miR-335 and miR-34a expression had even poorer overall survival. mi...Continue Reading

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Citations

Jun 21, 2016·International Journal of Molecular Sciences·Ming-Ming TsaiKwang-Huei Lin
Oct 9, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Long-Ji LuoJin-Hai Tang
Oct 28, 2017·Clinical Epigenetics·Alejandra Sandoval-BórquezAlejandro H Corvalán
Sep 15, 2017·Oncotarget·Yue ZhangYue-Hua Jiang
May 2, 2019·World Journal of Gastrointestinal Oncology·Ana Flávia Teixeira RossiAna Elizabete Silva
Mar 19, 2020·OncoTargets and Therapy·Yingping ZhuJun Jiang
Oct 23, 2019·International Journal of Molecular Sciences·Jennie OngJoost Kluiver
May 29, 2021·OncoTargets and Therapy·Lingling YeQuan An Zhang

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