miR-337 can be a key negative regulator in melanoma

Cancer Biology & Therapy
Wanan XiaoLijie Tian

Abstract

Incidence of melanoma is increasing annually worldwide. There remains a lack of suitable treatment methods which can significantly improve the 5-year survival rates of patients. It is established that micro RNAs (miRNAs) have important roles in the diagnosis and treatment of cancer. MiR-337 had been reported to regulate the development of variety of cancers, as a cancer suppressive factor. In our research we found that miR-337 had a lower expression in melanoma than adjacent tissues. The patients who had a lower miR-337 also got a worse survival. MiR-337 could target STAT3 to regulate the occurrence and development of melanoma.  In summary, our findings suggest that the miR-337/STAT3 axis may serve as a potential target for the treatment of melanoma.

References

Mar 17, 2006·Cancer Research·Tong-xin XieSuyun Huang
Aug 8, 2006·Biochemical and Biophysical Research Communications·Jie HongWeida Huang
Mar 27, 2007·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Liqing ZhuangPeter Hersey
Dec 5, 2012·Biochemical and Biophysical Research Communications·Keith M GilesPeter J Leedman
Jul 10, 2013·Cancer Cell International·Ting-Song YangZhen-Shun Song
Aug 2, 2013·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Eyal GreenbergGal Markel
Jan 16, 2014·Journal of Experimental & Clinical Cancer Research : CR·Zishu WangQiong Wu
Feb 12, 2014·Cancer Letters·Anna Gajos-MichniewiczMalgorzata Czyz
Dec 11, 2014·The Journal of Dermatology·Taisuke InadaHironobu Ihn
Jun 20, 2015·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Doug HannifordEva Hernando
Aug 23, 2016·Nature Cell Biology·Shani DrorCarmit Levy
Aug 31, 2016·Oncology Reports·Bingyu GuoKai Tao
Nov 30, 2016·Frontiers in Pharmacology·Andrea RussoMichele Reibaldi
Nov 30, 2016·BioFactors·Saeideh MomtazSeyed Mohammad Nabavi

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Citations

Jun 20, 2019·Cell Cycle·Liang XiaRuixiang Xia
Dec 9, 2020·Critical Reviews in Oncology/hematology·Zahra Sadat RazaviHamed Mirzaei
May 11, 2021·Frontiers in Oncology·Soudeh Ghafouri-FardMohammad Taheri

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Methods Mentioned

BETA
dissection
PCR
Assay

Software Mentioned

MIRDB

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