miR-340 predicts glioblastoma survival and modulates key cancer hallmarks through down-regulation of NRAS

Oncotarget
Danilo FioreGerolama Condorelli

Abstract

Glioblastoma is the most common primary brain tumor in adults; with a survival rate of 12 months from diagnosis. However, a small subgroup of patients, termed long-term survivors (LTS), has a survival rate longer then 12-14 months. There is thus increasing interest in the identification of molecular signatures predicting glioblastoma prognosis and in how to improve the therapeutic approach. Here, we report miR-340 as prognostic tumor-suppressor microRNA for glioblastoma. We analyzed microRNA expression in > 500 glioblastoma patients and found that although miR-340 is strongly down-regulated in glioblastoma overall, it is up-regulated in LTS patients compared to short-term survivors (STS). Indeed, miR-340 expression predicted better prognosis in glioblastoma patients. Coherently, overexpression of miR-340 in glioblastoma cells was found to produce a tumor-suppressive activity. We identified NRAS mRNA as a critical, direct target of miR-340: in fact, miR-340 negatively influenced multiple aspects of glioblastoma tumorigenesis by down-regulating NRAS and downstream AKT and ERK pathways. Thus, we demonstrate that expression of miR-340 in glioblastoma is responsible for a strong tumor-suppressive effect in LTS patients by down-regul...Continue Reading

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Citations

Jul 18, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Ondrej FialaJindrich Finek
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Nov 26, 2021·Radiology and Oncology·Andrej RenceljMaja Cemazar

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Datasets Mentioned

BETA
SF767

Methods Mentioned

BETA
GTPases
chip
PCR
transfection
FACS
flow
caspase assay
xenografts
xenograft
chips

Software Mentioned

GraphPadPrism
MIRANDA
GENESPRING ANOVA
BIOCONDUCTOR
Targetscan
GraphPad Prism
Leica Application Suite X ( LAS X )
GENESPRING

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