miR-34a inhibits the apoptosis of MDSCs by suppressing the expression of N-myc

Immunology and Cell Biology
Si ChenJinping Zhang

Abstract

Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of early myeloid progenitors, which possess strong immunosuppressive functions. MDSCs are found in increased numbers in infectious and inflammatory pathological conditions. However, whether microRNAs have a role in the expansion remains unclear. Here in our study, we found that overexpression of miR-34a could induce the expansion of MDSCs in the bone marrow and spleen both in chimera and transgenic mice. And further experiments demonstrated that miR-34a inhibited the apoptosis through reduced translation of N-myc without affecting the proliferation. Luciferase assay and western blotting experiments implied that N-myc is the direct target of miR-34a in MDSCs. Overexpressed mir-34a changes the cytokine expression profile in MDSCs and skewed the MDSCs to M1 phenotype. And miR-34a-overexpressed MDSCs significantly slowed down the tumor growth. Taken together, miR-34a contributes to the expansion of MDSCs by inhibiting the apoptosis via suppressing the expression of N-myc.

References

Jun 21, 1991·Science·S E KernB Vogelstein
Jun 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·B S EmanuelM C Glick
Dec 23, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yulia NefedovaDmitry Gabrilovich
Dec 7, 2005·Proceedings of the National Academy of Sciences of the United States of America·Nadia FelliCesare Peschle
Oct 4, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Je-In YounDmitry I Gabrilovich
Feb 7, 2009·Nature Reviews. Immunology·Dmitry I Gabrilovich, Srinivas Nagaraj
Apr 4, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Suzanne Ostrand-Rosenberg, Pratima Sinha
Jul 1, 2009·The Journal of Experimental Medicine·Lin WangHua Yu
Feb 2, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Donggou HeHui Xu
Jul 8, 2010·Immunity·Stefan KuchenRafael Casellas
Jul 21, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Melissa G LechnerAlan L Epstein
Sep 10, 2010·Methods in Molecular Biology·Virginia G de Yébenes, Almudena R Ramiro
Nov 27, 2010·European Journal of Immunology·Moshe ElkabetsChristian A J Vosshenrich
Oct 5, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marian L TurnerThomas Brocker
Mar 23, 2012·Nature Reviews. Immunology·Dmitry I GabrilovichVincenzo Bronte
May 1, 2012·Cell·Margaret S Ebert, Phillip A Sharp
May 1, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yang LiuQingqing Wang
Mar 2, 2013·Frontiers in Immunology·Ryan P SullivanTodd A Fehniger
Mar 28, 2013·Journal of Molecular Cell Biology·Wen-Chin YangPing-Ying Pan
Apr 5, 2013·Immunological Reviews·Lukas T Jeker, Jeffrey A Bluestone
Apr 17, 2013·Cell Cycle·Je-In Youn, Dmitry I Gabrilovich
Apr 23, 2013·Nature Immunology·Donald T GraciasPeter D Katsikis
Jan 1, 2014·OncoTargets and Therapy·Sylvanie SurgetJean-Christophe Bourdon
Jan 7, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Limin LiKe Zen
Jan 16, 2014·Oncoimmunology·Dinesh Chandra, Claudia Gravekamp
Nov 18, 2014·Immunity, Inflammation and Disease·Johannes PolzDaniela N Männel
Dec 6, 2014·Frontiers in Genetics·Mona KhalajChristopher Y Park
Dec 9, 2014·Cancer Biology & Therapy·Sandra L Romero-CordobaAlfredo Hidalgo-Miranda
Apr 18, 2015·Cell Death and Differentiation·B ZhangB R Calvi

❮ Previous
Next ❯

Citations

Dec 18, 2018·Frontiers in Immunology·Snehil BudhwarKiran Singh
Nov 3, 2020·Frontiers in Immunology·Elham SafarzadehBehzad Baradaran
Feb 17, 2021·Cellular Immunology·Maria Dulfary Sanchez-PinoAugusto C Ochoa
Mar 26, 2021·Frontiers in Cell and Developmental Biology·Wen Jess LiDean G Tang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis