miR-363-3p Inhibits Osteosarcoma Cell Proliferation and Invasion via Targeting SOX4.

Oncology Research
Kejun WangFen Lu

Abstract

miR-363-3p has been shown to suppress tumor growth and metastasis in various human cancers. However, the function of miR-363-3p in osteosarcoma (OS) has not been determined. In our study, we found that the expression of miR-363-3p was significantly downregulated in OS tissues compared with adjacent normal tissues. miR-363-3p expression was associated with the poor overall survival rate of OS patients. Moreover, we found that overexpression of miR-363-3p markedly inhibited the proliferation, migration, and invasion of U2OS and MG63 cells. Moreover, we found that SOX4 was a direct target of miR-363-3p in OS cells. Overexpression of miR-363-3p significantly inhibited the expression of SOX4. Expression levels of miR-363-3p and SOX4 were negatively correlated in OS tissues. Finally, we found that restoration of SOX4 attenuated the suppressive effects of miR-363-3p on the proliferation, migration, and invasion of U2OS and MG63 cells. Therefore, our findings demonstrated that miR-363-3p served as a tumor suppressor in OS tissues by targeting SOX4.

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Citations

Jul 4, 2020·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Zhijuan YuXiujuan Li
Oct 17, 2019·Frontiers in Genetics·Christopher M SmithGyorgy Hutvagner
Feb 10, 2021·Cell Death Discovery·Na JiangLei Shang
Oct 16, 2020·Journal of the National Cancer Institute·Xinyi LiuXiaowei Wang
Sep 22, 2021·Clinical and Experimental Pharmacology & Physiology·Qiwen PanYueqing Li

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Methods Mentioned

BETA
Transfection
PCR
Assay
Protein Assay
electrophoresis

Software Mentioned

Image
TargetScan7
TargetScan
GraphPad Prism
Pro Plus

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