miR-377 functions as a tumor suppressor in human clear cell renal cell carcinoma by targeting ETS1

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Ruiyan WangPeilong Ma

Abstract

Clear cell renal cell carcinoma (ccRCC) is the most common form of neoplasm occurring in the adult kidney. Although significant advances have been made in treatment for ccRCC, a significant percent of patients have no benefit from currently available treatment option. MicroRNAs (miRNAs) have been reported to play central roles in regulating tumor progression, and are being explored as potentially more effective therapies and diagnostic tools for various cancers. The transcription factor E26 transformation specific-1 (ETS1) is believed to be intimately involved in tumor progression, and is frequently upregulated in tumors, including ccRCC. However, few studies have investigated the implications of ETS1 in ccRCC, and no studies have investigated the dysregulated mechanisms responsible for aberrant ETS1 expression in ccRCC. We used databases, clinical samples and target prediction algorithms to investigate aberrant miR-377 expression and potential targets in ccRCC. Our results indicate that miR-377 is downregulated in ccRCC, and that miR-377 can regulate the expression of ETS1. Further, using cell cycle analysis, MTT, luciferase and knockdown experiments, we found evidence to suggest that ETS1 is central in the development of the ...Continue Reading

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Citations

Oct 17, 2015·International Journal of Molecular Sciences·Cuiying LiuDongguo Li
Aug 25, 2015·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Baojun FangGang Li
Sep 24, 2015·Seminars in Cancer Biology·Jürgen Dittmer
Sep 18, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Weihua ChangPing Chen
Apr 9, 2019·Cell Biology International·Wei LiFei Wang
Feb 15, 2017·Journal of Experimental & Clinical Cancer Research : CR·Qinghua CaoLiantang Wang
Oct 21, 2015·The International Journal of Biological Markers·Michal FedorkoMohamed I Nussir
Mar 30, 2021·Frontiers in Cell and Developmental Biology·Chao HuTongyu Zhu

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