MiR-378 promotes the cell proliferation of osteosarcoma through down-regulating the expression of Kruppel-like factor 9

Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire
Ningning PengXu Guo

Abstract

MicroRNAs (miRNAs) are small non-coding RNAs that play important roles in a variety of biological processes. Dysregulation of miRNAs is tightly associated with the malignancy of cancers. Aberrant expression of miR-378 has been observed in human cancers; however, the function of miR-378 in osteosarcoma (OS) remains largely unknown. Here, we showed that miR-378 was highly expressed in human OS tissues and cell lines. Overexpression of miR-378 significantly promoted the cell proliferation of OS cells. Molecular studies identified Kruppel-like factor-9 (KLF9) as a functional downstream target of miR-378. MiR-378 directly bound to the mRNA 3'-UTR region of KLF9 and suppressed the expression of KLF9. Highly expressed KLF9 reversed the promoting effect of miR-378 on the proliferation of OS cells. The expression level of miR-378 was negatively correlated with that of KLF9 in OS tissues. Collectively, our results demonstrated the molecular interaction between miR-378 and KLF9, indicating the therapeutic potential of miR-378 for OS.

References

Jun 19, 1986·The New England Journal of Medicine·M P LinkJ A Kirkpatrick
Mar 24, 2007·American Journal of Physiology. Gastrointestinal and Liver Physiology·Frank A SimmenRosalia C M Simmen
Dec 14, 2007·Proceedings of the National Academy of Sciences of the United States of America·Daniel Y LeeBurton B Yang
May 15, 2008·Pathology International·Ling KangMaode Lai
Mar 31, 2009·International Journal of Cancer. Journal International Du Cancer·Lisa MirabelloSharon A Savage
Oct 21, 2010·Physiological Reviews·Beth B McConnell, Vincent W Yang
Jun 20, 2012·Proceedings of the National Academy of Sciences of the United States of America·Florian SpörlAchim Kramer
Dec 19, 2012·Cancer Biomarkers : Section a of Disease Markers·L LodewijkM R Vriens
Apr 1, 2014·Gynecologic Oncology·John K ChanDaniela Matei
Jan 7, 2015·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Jichun MaZhaoqun Deng
Jan 31, 2015·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Qi-Xian WangJun Xiao
Sep 9, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Qi-Guang ChenChui-Ze Kong
Oct 23, 2015·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Yoshiaki MizuguchiEiji Uchida
Jan 11, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Gillian BrowneJane B Lian
Jun 11, 2016·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Hui MaQianming Chen
Dec 7, 2016·Frontiers in Molecular Neuroscience·Ming Ming Wen
Sep 14, 2017·International Journal of Molecular Medicine·Shengjie LiZhen Yang

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Citations

Apr 6, 2019·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·G M VieraM S Brassesco
Feb 16, 2020·Journal of Clinical Laboratory Analysis·Yan Zhang, Hongjie Xu
Feb 16, 2020·Oncogenesis·Maria Grazia TuponeDonatella Del Bufalo
Jan 1, 2020·Journal of Experimental & Clinical Cancer Research : CR·Chenyu DingDezhi Kang
Dec 19, 2020·Open Medicine·Guanyu ZhangZhenfang Xiong
Aug 19, 2021·Neurochemical Research·Pengfei GaoXianlong Zhang

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