MiR-381 inhibits epithelial ovarian cancer malignancy via YY1 suppression

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Bairong XiaGe Lou

Abstract

Epithelial ovarian cancer (EOC) is a common type of gynecologic cancer, which accounts for the majority of deaths among all gynecologic malignant tumors in developed countries. A series of recent studies suggested that miR-381 might play important roles in the development of various cancer types. However, the biological function of miR-381 in EOC remains to be investigated. We examined the levels of miR-381 expression in EOC tissues and cell lines. We identified miR-381 target genes by bioinformatic prediction. We also characterized the phenotype regarding cell proliferation, cell migration, and cell invasion in EOC cells lines with altered expression levels of both miR-381 and its target gene, YY1. The expression levels of miR-381 were downregulated in EOC tissues and cell lines. Overexpression of miR-381 significantly inhibited EOC cell proliferation, migration, and invasion. Restoration of YY1 expression partially reversed the phenotype induced by miR-381 overexpression. Knockdown of miR-381 target gene, YY1, mimicked the phenotype induced by miR-381 overexpression. MiR-381 regulated EOC cell through miR-381/YY1/p53 and miR-381/YY1/Wnt signaling axis. We concluded that miR-381 inhibited EOC cell proliferation, migration, and...Continue Reading

References

Sep 7, 2000·Current Opinion in Oncology·R E Bristow
Sep 10, 2002·The Lancet Oncology·Mark Harries, Martin Gore
May 4, 2004·Biochemical and Biophysical Research Communications·Tatiana YakovlevaGeorgy Bakalkin
Jun 24, 2004·Cell·Guangchao SuiYang Shi
Apr 5, 2005·Nature Genetics·Azra KrekNikolaus Rajewsky
Mar 22, 2006·Expert Opinion on Therapeutic Targets·Chi-Chung WangPan-Chyr Yang
Oct 10, 2006·Carcinogenesis·Hirotaka Osada, Takashi Takahashi
Nov 8, 2007·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·T A GatcliffeR F Holcombe
Oct 29, 2008·Genome Research·Robin C FriedmanDavid P Bartel
Mar 4, 2009·Nature Cell Biology·Julia WinterSven Diederichs
Oct 27, 2009·Gynecologic Oncology·Daniela E Matei, Kenneth P Nephew
Jun 8, 2010·Nucleic Acids Research·Noriko N YokoyamaMarian L Waterman
Jan 18, 2012·Critical Reviews in Oncogenesis·Qiang ZhangGuangchao Sui
Apr 12, 2012·Carcinogenesis·Marilena V Iorio, Carlo M Croce
Apr 25, 2012·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Teresa GranatoEmanuela Anastasi
May 18, 2012·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Sacha I RothschildOliver Gautschi
Jan 15, 2015·Molecular and Cellular Biology·Qian ZhangXishan Wang
Mar 10, 2015·Cancer Letters·Xinbing SuiHongming Pan
Mar 25, 2015·Molecular and Cellular Biology·Yen-Nien LiuKathleen Kelly
Apr 15, 2015·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Xiaoping LiJun Liu
Sep 1, 2015·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yan LiangYong Li

❮ Previous
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Citations

Aug 27, 2016·International Journal of Molecular Sciences·Weishen ChenZiji Zhang
Nov 5, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yan ZhangYong Lin
Apr 14, 2017·Cell Death & Disease·Hsiao-Chi TsaiChih-Hsin Tang
Jan 13, 2018·International Journal of Cancer. Journal International Du Cancer·Levon M Khachigian
Feb 15, 2017·Journal of Experimental & Clinical Cancer Research : CR·Qinghua CaoLiantang Wang
Jan 6, 2018·Cancer Biology & Therapy·Yan ZhangChang Liu
Dec 28, 2018·Acta Biochimica Et Biophysica Sinica·Hui ZhouFusheng Wan
Jun 8, 2019·International Journal of Molecular Medicine·Guanen QiaoWei Bian
Jan 8, 2020·Journal of Experimental & Clinical Cancer Research : CR·Dan JinGuoming Su
Jun 18, 2020·OncoTargets and Therapy·Hai-Feng MaDa-Hai Zhang
Dec 10, 2019·Clinical & Experimental Metastasis·Padacherri Vethil JishnuShama Prasada Kabekkodu
Oct 31, 2020·Cellular Oncology (Dordrecht)·Ali Fatehi Hassanabad, Kelsey T MacQueen
Aug 25, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Li-Ying ZhanQiang-Min Huang
Jun 18, 2021·Indian Journal of Pathology & Microbiology·Hyunsung KimSeung Sam Paik

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