MiR-382 inhibits cell growth and invasion by targeting NR2F2 in colorectal cancer

Molecular Carcinogenesis
Baoguo ZhouYuli Wang

Abstract

Colorectal cancer (CRC) is one of the leading causes of cancer death worldwide. MiR-382 has been found to have a decreased expression and the ability to suppress tumorigenesis in certain cancers. However, the role of miR-382 in CRC has not been sufficiently investigated. NR2F2 (also known as COUP-TFII), a member of the steroid/thyroid receptor superfamily, is often aberrantly activated in various tumors, but it is currently unclear whether NR2F2 may be a target of miR-382. In the present study, we investigated the role of miR-382 in CRC and identified the regulation of NR2F2 by miR-382. We observed that miR-382 was aberrantly downregulated in CRC. Transfection with miR-382 mimics impeded the growth, migration, and invasion of CRC cells. The direct binding of miR-382 to the 3' untranslated region (3' UTR) of NR2F2 was confirmed using a luciferase reporter gene assay. We showed that the relative expression levels of NR2F2 were significantly higher in CRC tissues compared with normal adjacent mucosa. A Kaplan-Meier analysis indicated that patients with high NR2F2 expression had a poor overall survival. Knockdown of NR2F2 inhibited CRC cell growth, migration, and invasion. Ectopic expression of NR2F2 mitigated miR-382 suppression o...Continue Reading

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Citations

Jul 26, 2017·Epigenetics : Official Journal of the DNA Methylation Society·Katharina HeßelbachMatjaz Humar
Dec 7, 2019·British Journal of Cancer·Sela T Po'uhaMaria Kavallaris
Nov 23, 2019·Cancer Biotherapy & Radiopharmaceuticals·Ye JinLingli Yu
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Sep 5, 2020·Cancer Management and Research·Xiaolei ZhaoJunqing Hou
Feb 20, 2021·Frontiers in Microbiology·Ying ZhaoXueqin Ni

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