miR-411 regulated ITCH expression and promoted cell proliferation in human hepatocellular carcinoma cells

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Kunkun XiaShuijun Zhang

Abstract

Hepatocellular carcinoma (HCC) is one of the most common human malignancies and the third most common cause of cancer mortality in the world. In this study, we report that miR-411 expression is markedly upregulated in HCC cells and HCC tissues compared with normal control tissues and cells. Previous studies have shown that miR-411 plays a crucial role in a variety of biological processes in various human cancer cells. However, the specific function of miR-411 in HCC remains unclear. Ectopic expression of miR-411 promoted the proliferation and anchorage-independent growth of HCC cells, whereas inhibition of miR-411 reduced this effect. Bioinformatics analysis further revealed ITCH, a putative tumor suppressor as a potential target of miR-411. Data from luciferase reporter assays showed that miR-411 directly binds to the 3'-untranslated region (3'-UTR) of ITCH mRNA and repressed expression at both transcriptional and translational levels. In functional assays, miR-411 promoted HCC cell proliferation, which could be suppressed by miR-411-in. Taken together, our data provide convincing evidence that miR-411 functions as an onco-miRNA, which was associated with cell proliferation of HCC, and its oncogenic effect is mediated chiefly ...Continue Reading

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Citations

Jan 28, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·M BraoudakiE Kanavakis
Jun 7, 2016·Biochemical and Biophysical Research Communications·Yunda ZhangQi Luo
Aug 25, 2016·Annals of Hematology·Chunyan ZhangYa-Ping Tian
Feb 18, 2018·Environmental Science and Pollution Research International·Ning XuZhange Yu
Oct 20, 2019·Cell Cycle·Wen-Cai ZhangLuo-Sha Zhao
Jul 15, 2017·The International Journal of Biological Markers·Xintao ZhangZhiming Cai
Jan 14, 2021·International Journal of Molecular Sciences·Han Yeoung LeeJong Kook Park

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