MiR-424 functions as a tumor suppressor in glioma cells and is down-regulated by DNA methylation

Journal of Neuro-oncology
Chen JinYugang Jiang

Abstract

Glioma is one of the most lethal malignancies, and increasing reports revealed that microRNAs (miRNAs), a class of small non-coding RNAs, play a critical role in the development and pathology of human gliomas. MiR-424 has been found to be dysregulated in many different types of human cancers. However, the clinical significance and function of miR-424 in glioma remains unclear. Here, based on RTq-PCR analysis in 148 clinical specimens, we found miR-424 expression was significantly decreased in glioma tumor tissues than in adjacent non-neoplastic brain tissues, and decreased miR-424 expression was associated with glioma KPS (P = 0.009) and high grades (P = 0.029). In vitro cellular function assays further revealed that miR-424 inhibited cell invasion and migration, and promoted cell apoptosis. In addition, based on DNA methylation analysis on clinical specimens and cell lines, we found miR-424 promoter CpG island was frequently methylated and correlated with glioma high grades (P = 0.035) and IDH mutation status (P = 0.042). Moreover, the promoter CpG island was demethylated by 5-aza-2'-deoxycytidine treatment in a time-dependent manner and the expression levels of miR-424 were gradually induced and increased. Taken together, our...Continue Reading

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Citations

Apr 15, 2018·Bioscience Reports·Zhigang TanYugang Jiang
Feb 27, 2020·Acta Obstetricia Et Gynecologica Scandinavica·Milosz WilczynskiAndrzej Malinowski
Aug 15, 2019·Experimental and Therapeutic Medicine·Jialiang WangWei Dong
Apr 3, 2020·Molecular and Cellular Biochemistry·Sheng-Li SunMei-Yi Tao
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Dec 29, 2020·Seminars in Cancer Biology·Md Sahab UddinGhulam Md Ashraf
Oct 17, 2020·OncoTargets and Therapy·Shulin LiXiangwei Wang
Mar 7, 2021·Journal of Gastrointestinal Cancer·Zahra Nouri GhonbalaniEhsan Khalili
Jun 22, 2021·European Journal of Pharmacology·Fatemeh GheidariMasoud Soleimani

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