PMID: 26779781Jan 19, 2016Paper

Mir-451 Correlates with Prognosis of Renal Cell Carcinoma Patients and Inhibits Cellular Proliferation of Renal Cell Carcinoma

Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
Shuying ZhuXian Su

Abstract

Renal cell carcinoma (RCC) is a common cancer, accounting for about 2-3% of all adult cancers. A novel diagnostic biomarker and therapeutic target is urgently needed. However, the function of miR-451 in RCC remains unknown. Here, we explored the role of miR-451 in RCC. MiR-451 levels in RCC tissues and cells were tested by qRT-PCR. Cells were transfected miR-451 mimics or miR-451 ASO by Lipofectamine. The cellular proliferation was tested by MTT analysis. The apoptosis rate was revealed by FACS. Bioinformatics algorithms from TargetScanHuman were used to predict the target genes of miR-451. The PSMB8 protein level was tested by Western blot. The interaction between miR-451 and PSMB8 was confirmed by dual luciferase assays. MiR-451 level of RCC tissues was lower than in normal tissues, which was correlated to the patients' survival rate. Low levels of miR-451 in RCC cells promoted the growth of cells and inhibited cells apoptosis and vice versa. The targeted gene of miR-451 is PSMB8. MiR-451 acts as an anti-oncogene in RCC. Our data offer a new therapeutic target for further research.

Citations

Jan 4, 2017·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Wei XieKebin Zhang
Jun 6, 2018·Nature Reviews. Urology·Sophie C JoostenManon van Engeland
Oct 19, 2017·Cancer Metastasis Reviews·Yulin ChenXing Guo
Apr 13, 2019·Cellular & Molecular Biology Letters·Liang SunShu Meng
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Jan 7, 2017·Molecular Cancer Research : MCR·Kefeng WangXiaonan Chen
Dec 18, 2020·Frontiers in Oncology·Soudeh Ghafouri-FardMohammad Taheri
May 1, 2021·Seminars in Cell & Developmental Biology·Saife N LoneMuzafar A Macha
Sep 14, 2021·MicroRNA·Saiedeh Razi SoofiyaniTohid Ghasemnejad

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