MiR-454-3p-Mediated Wnt/β-catenin Signaling Antagonists Suppression Promotes Breast Cancer Metastasis

Theranostics
Liangliang RenLili Jiang

Abstract

The Wnt/β-catenin pathway is constitutively active and promotes multiple tumor processes, including breast cancer metastasis. However, the underlying mechanism by which the Wnt/β-catenin pathway is constitutively activated in breast cancer metastasis remains unclear. Inhibition of Wnt antagonists is important for Wnt/β-catenin signaling activation, and post-transcriptional regulation of these antagonists by microRNAs (miRNAs) might be a possible mechanism underlying signaling activation. Regulation of nuclear pre-mRNA domain-containing 1A (RPRD1A) is a known inhibitor of cell growth and Wnt/β-catenin signaling activity, but the function and regulatory mechanism of RPRD1A in breast cancer have not been clarified. The aim of this study was to understand how regulators of the Wnt/β-catenin pathway may play a role in the metastasis of this cancer. Methods: RPRD1A expression and its association with multiple clinicopathological characteristics was analyzed immunohistochemically in human breast cancer specimens. miR-454-3p expression was analyzed using real-time PCR. RPRD1A or miR-454-3p knockdown and overexpression were used to determine the underlying mechanism of their functions in breast cancer cells. Xenografted tumor model, 3D ...Continue Reading

Citations

Feb 23, 2020·Cancers·Rashidah BaharudinNurul Syakima Ab Mutalib
Jul 1, 2020·Journal of Clinical Medicine·Daniel P ZalewskiAnna Bogucka-Kocka
Oct 11, 2019·Cells·Mohammad Mijanur RahmanTrygve O Tollefsbol
Mar 20, 2020·Molecular Cancer·Francesca CrudeleStefano Volinia
Aug 22, 2020·Cancer Management and Research·Xiaolan WenWen Zhang
Sep 10, 2020·OncoTargets and Therapy·Kun ZhangGuiying Wang
Jul 17, 2020·Non-coding RNA·Jun Sheng Wong, Yoke Kqueen Cheah
Jun 5, 2020·Seminars in Cancer Biology·Dipta SenguptaSamir Kumar Patra
Nov 19, 2020·BioMed Research International·Xinhong LiuXin Zhao
May 18, 2020·Clinical Breast Cancer·Nupur Mukherjee, Chinmay Kumar Panda
Feb 20, 2021·Experimental Cell Research·Madhumathy G NairT S Sridhar
Mar 20, 2021·Seminars in Cancer Biology·Rui ZhangSuling Liu
May 22, 2021·Frontiers in Oncology·Xiao-Lan QianChen Ni
Jun 24, 2021·Journal of Orthopaedic Surgery and Research·Shan CongLi Luo

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Methods Mentioned

BETA
PCR
electrophoresis
Assay
transfection
immunoprecipitation assay

Software Mentioned

TargetScan
miRANDA
SPSS
GSEA

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