miR-483-3p plays an oncogenic role in esophageal squamous cell carcinoma by targeting tumor suppressor EI24

Cell Biology International
Jiaojiao MaYongzhan Nie

Abstract

microRNAs (miRNAs), through negatively regulating their target genes, influence the development and progression of many cancers. Previously, we found miR-483 was overexpressed in esophageal squamous cell carcinoma (ESCC) tissues, and its overexpression was negatively correlated with the prognosis and positively correlated with multidrug resistance of ESCC, but whether it could affect the biological role of proliferation and migration in ESCC cell lines is unknown. In the present study, we found miR-483-3p was overexpressed in ESCC cell lines as compared with the normal esophageal squamous epithelial cell line. Functional experiments in vitro showed that miR-483-3p could promote the proliferation, migration, transformation of cell cycle from G1 phase to G2 phase of ESCC cells and could inhibit cells' sensitivity to chemotherapy drugs. Nude mouse tumorigenicity assay indicated that miR-483-3p could promote the growth of ESCC cells in vivo. Western blot assay showed that ectopic expression of miR-483-3p in ESCC cells could downregulate the protein level of etoposide induced 2.4 (EI24), which is a tumor suppressor and has not been reported in ESCC. Luciferase reporter assay demonstrated that EI24 was a direct target of miR-483-3p. ...Continue Reading

References

Dec 14, 1999·Molecular and Cellular Biology·Z GuG P Zambetti
Nov 6, 2007·FEBS Letters·Christina N MorkRemco A Spanjaard
Jan 14, 2010·Biochemical and Biophysical Research Communications·Qiong WuDaiming Fan
Oct 5, 2010·Nature Reviews. Drug Discovery·Ramiro GarzonCarlo M Croce
Dec 15, 2010·International Journal of Cancer. Journal International Du Cancer·Dipanjana Mazumder IndraChinmay Kumar Panda
Aug 24, 2011·Endocrine-related Cancer·Deniz M ÖzataWeng-Onn Lui
Feb 5, 2013·Lancet·Arjun PennathurJames D Luketich
Jan 30, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Ute Warnecke-EberzElfriede Bollschweiler
Feb 6, 2015·CA: a Cancer Journal for Clinicians·Lindsey A TorreAhmedin Jemal

❮ Previous
Next ❯

Citations

Oct 25, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Changshan SongZhigang Wang
Mar 21, 2017·Expert Review of Gastroenterology & Hepatology·Wanli YangLiu Hong
May 9, 2018·Angiogenesis·Anna Janaszak-JasieckaRafal Bartoszewski
Aug 26, 2017·Expert Review of Gastroenterology & Hepatology·Wanli YangLiu Hong
Apr 4, 2019·Journal of Cellular Physiology·Wei FengShaoqing Ju
May 24, 2017·International Journal of Molecular Medicine·Zhenyu ShenShenghua Sun
Feb 18, 2017·Cancer Biomarkers : Section a of Disease Markers·Liying XueYadi Wang
Aug 2, 2017·Cancer Biomarkers : Section a of Disease Markers·Shuaiyu ZhengJiyuan Li
Dec 29, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yanwen MaoBing Guo
Jul 19, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·YueJiao WangNing Zhang
Feb 21, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Maofeng WangXiyong Liu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Antisense Oligonucleotides: ND

This feed focuses on antisense oligonucleotide therapies such as Inotersen, Nusinursen, and Patisiran, in neurodegenerative diseases including amyotrophic lateral sclerosis.

Cell Migration in Cancer and Metastasis

Migration of cancer cells into surrounding tissue and the vasculature is an initial step in tumor metastasis. Discover the latest research on cell migration in cancer and metastasis here.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.