miR-484/MAP2/c-Myc-positive regulatory loop in glioma promotes tumor-initiating properties through ERK1/2 signaling

Journal of Molecular Histology
Renhui YiMuyun Luo

Abstract

Glioma is the most common intracranial malignant tumor. Cancer stem cells (CSCs) are resistant to chemotherapy and radiotherapy, and are closely related to cancer metastasis and recurrence. In this study, we aimed to explore the effect of miR-484 on glioma stemness and the underlying mechanism involved. miR-484 enhanced glioma tumor-initiating properties in vitro and in vivo. Moreover, miR-484 was shown to directly target MAP2, resulting in activation of ERK1/2 signaling and promotion of stemness in glioma. The ERK1/2 signaling facilitated the formation of a miR-484/MAP2/c-Myc positive feedback loop in glioma. High miR-484 expression predicted a poor prognosis for glioma patients, and high MAP2 expression predicted a good prognosis for glioma patients. Low miR-484 expression and high MAP2 expression was associated with the best prognosis in glioma. Our study suggests that miR-484 and MAP2 can be utilized as predictors for the clinical diagnosis and prognosis of glioma, and miR-484 and MAP2 are potential targets for the treatment of glioma.

References

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Citations

Jun 8, 2019·Molecular Medicine Reports·Qian-Kun JiBao-Zhe Jin
Sep 20, 2020·BMC Medical Genomics·Anna V KudryavtsevaAnastasiya V Snezhkina
Feb 23, 2020·Cancer Biomarkers : Section a of Disease Markers·Andrea RitterThalia Erbes
Feb 18, 2020·Cancer Biomarkers : Section a of Disease Markers·Weijia ZhangHai Zeng
Oct 19, 2020·Current Cancer Drug Targets·Milad AshrafizadehManoj Garg

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Methods Mentioned

BETA
flow cytometry
xenograft
chip
protein assay
Assay
Co-immunoprecipitation
immunoprecipitation
PCR
transfection
Co-IP

Software Mentioned

PROMO
JASPAR
Chipbase
GSEA
miRDB
RNA22
PICTAR5
miRWalk
TargetScan
miRanda

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