miR-487a promotes progression of gastric cancer by targeting TIA1

Biochimie
Xuefeng YangShouyang Yu

Abstract

Gastric cancer (GC) is one of the most common malignancies as well as the third leading cause for cancer-related death. Molecular basis of GC are essential and critical for its therapeutic treatment, but still remain poorly understood. T-cell intracellular antigen-1 (TIA1) extensively involves in cancer progression, whereas its role and regulation mechanism in GC have not been revealed. In the present study, we found that TIA-1 protein level was down-regulated in GC tissues and TIA1 inhibited proliferation and promoted apoptosis of GC cells. Then, we used bioinformatics to predict miR-487a as the upstream regulator of TIA1 and we also observed an inverse correlation between miR-487a level and TIA-1 protein level in GC tissues. Next, we demonstrated that miR-487a directly targeted TIA1 via binding to its 3'-untranslated region. Furthermore, we investigated the role of miR-487a-TIA1 pathway in the growth of GC cells both in vitro and in vivo. The repression of TIA-1 by miR-487a promoted cell proliferation and suppressed cell apoptosis in vitro, and the knockdown of miR-487a had the opposite effects. Finally, we demonstrated that miR-487a promoted the development of gastric tumor growth in xenograft mice by targeting TIA-1. These ...Continue Reading

Citations

Dec 24, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jie Zhou, Qing Chen
Jul 10, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Linlin ShaoWael El-Rifai
May 16, 2020·Acta Biochimica Et Biophysica Sinica·Zhiqian GuShoujun Zhao
Feb 23, 2019·World Journal of Gastrointestinal Oncology·Noémie LegrandCyril Sobolewski
Jan 28, 2021·Acta Biochimica Et Biophysica Sinica·Yue ShuShouyang Yu

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