miR-495 mediates metabolic shift in glioma cells via targeting Glut1

The Journal of Craniofacial Surgery
Sheng NieSun Jie

Abstract

Cancer cell metabolism is often characterized by a shift from an oxidative to a glycolytic bioenergetics pathway, a phenomenon known as the Warburg effect. Whether the deregulation of microRNAs contributes to the Warburg effect remains largely unknown. Here, we show that miR-495 expression is decreased and thus induces a metabolic shift in glioma cells. miR-495 performs this function by increasing the expression of Glut1, leading to the increase of glucose uptake and lactate production. The altered metabolism induced by miR-495 results in the rapid growth of cancer cells. These results identify miR-495 as a molecular switch involved in the orchestration of the Warburg effect in glioma cells via targeting the expression of Glut1.

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Citations

Nov 7, 2015·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Ping XuHongwei Zhu
Dec 15, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Jia-Ying FanYan-Qing Huang
Jun 18, 2016·Cancer Biomarkers : Section a of Disease Markers·Liang-Qing LiWen-Jun Xie
Aug 1, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Hongbao GuoYue Zhong
Jan 13, 2018·Future Oncology·Guangke YuanZhaode Jiao
Jun 21, 2020·Signal Transduction and Targeted Therapy·Lei LiuShouping Xu
Apr 8, 2018·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Robert J HarrisBenjamin M Ellingson
Aug 9, 2020·OncoTargets and Therapy·Wei HanWei Guan
Jun 25, 2017·Molecular and Cellular Biochemistry·Jiaying ChenDongshu Du
Jun 3, 2021·International Journal of Molecular Sciences·Anna Maria ReussNicolai Savaskan

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