miR-497-5p inhibits tumor cell growth and invasion by targeting SOX5 in non-small-cell lung cancer

Journal of Cellular Biochemistry
Gang LiHong Ren

Abstract

MicroRNAs plays an important role in the ccurrence and development of non-small-cell lung cancer (NSCLC). miR-497-5p has been reported to function as a tumor suppressor in various cancers. However, the role of miR-497-5p in NSCLC remains poorly understood. In this study, we aimed to investigate the biological role and potential molecular mechanism of miR-497-5p in NSCLC. Our results showed that the messenger RNA (mRNA) expression level of miR-497-5p was notably downregulated in human NSCLC tissues and cell lines. miR-497-5p overexpression remarkably inhibited NSCLC cell proliferation and increased cell apoptosis in A549 and H460 cells, whereas inhibition of miR-497-5p had an opposite effect. The ability of cell migration and invasion was inhibited by miR-497-5p overexpression but was increased by miR-497-5p inhibition. Moreover, our findings indicated that SOX5 was a direct target of miR-497-5p. The protein and mRNA expression levels of SOX5 in A549 cells were remarkably inhibited by miR-497-5p overexpression but was upregulated by miR-497-5p inhibition. Furthermore, SOX5 overexpression notably reversed the effect of miR-497-5p mimic on NSCLC cell proliferation, cell apoptosis, cell migration, and invasion. Taken together, thes...Continue Reading

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Citations

Mar 12, 2020·Anti-cancer Agents in Medicinal Chemistry·Poonam VermaSaurav Sarkar
Mar 29, 2020·Technology in Cancer Research & Treatment·Jing-Jing ZhengHua Shi
Mar 15, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Kun WuLong Ma
Apr 8, 2021·Laboratory Investigation; a Journal of Technical Methods and Pathology·Ri ChenHeng Zhang
Nov 14, 2021·Journal of Cardiothoracic Surgery·Jiangwei HuGuoliang Lou

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