Abstract
Downregulation of microRNA-520a-3p (miR-520a-3p) has been demonstrated in several cancers, and miR-520a-3p has been shown to inhibit tumor progression, indicating its potential role as a tumor suppressor. In this study, we found that miR-520a-3p was also downregulated in epithelial ovarian cancer (EOC) tissues and cell lines. Functional assays showed that ectopic expression of miR-520a-3p suppressed EOC cell proliferation, invasion, and epithelial-mesenchymal transition (EMT) and induced cell cycle arrest in vitro. Similarly, overexpression of miR-520a-3p inhibited tumor growth and metastasis in vivo. Mechanistically, suppressor of variegation 39H1 (SUV39H1) was identified as a novel target of miR-520a-3p through biomedical databases and dual-luciferase reporter assay. Subsequently, SUV39H1 was observed to be negatively regulated by miR-520a-3p at the mRNA and protein levels, and inversely correlated with miR-520a-3p expression in EOC tissues. Furthermore, overexpression of SUV39H1 reversed the suppressive effects of miR-520a-3p in EOC cells. Collectively, these results suggest that the miR-520a-3p/SUV39H1 axis may contribute to EOC cell proliferation and metastasis, revealing miR-520a-3p as a potential therapeutic target for t...Continue Reading
References
Nov 10, 2001·Cell·A H PetersT Jenuwein
Sep 17, 2004·Nature·Victor Ambros
Jan 24, 2007·CA: a Cancer Journal for Clinicians·Ahmedin JemalMichael J Thun
Feb 28, 2008·Physiological Genomics·Chunxiang Zhang
Jan 13, 2009·Gynecologic Oncology·Kristy ShieldGregory E Rice
Feb 11, 2012·Virchows Archiv : an International Journal of Pathology·Jaime Prat
Sep 20, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Dorothy Ngo-Yin FanChun-Ming Wong
Nov 26, 2013·Methods in Molecular Biology·Kemal Uğur TüfekciSermin Genç
May 2, 2017·Oncogenesis·T YuX Li
Oct 17, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Huicong LiJun Shi
May 29, 2018·CA: a Cancer Journal for Clinicians·Lindsey A TorreRebecca L Siegel
Aug 12, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Butian ZhangJinlan Jiang
Aug 18, 2018·Journal of Cellular and Molecular Medicine·Mingzhi CaiLisheng Cai
Aug 31, 2018·Cell Death & Disease·Jing ZhangYi Lin
Sep 13, 2018·Journal of Cellular Physiology·Chang-Long BiYi-Li Fu
Sep 25, 2018·NPJ Precision Oncology·Soochi KimYong Sang Song
Sep 29, 2018·Pathology, Research and Practice·Xianfeng QuGuiyang Wu
Oct 12, 2018·Open Biology·Hongxu LiuTao Yu
Dec 18, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Jingwei LiHuian Feng
Feb 17, 2019·Journal of Experimental & Clinical Cancer Research : CR·Xiaolan ZhuYuefeng Li
May 28, 2019·Cell Cycle·Hao GaoXiaoqing Guo
Sep 20, 2019·Journal of Cellular Biochemistry·Cuiping YangJunli Zuo
Oct 11, 2019·Journal of Biochemistry·Jun ChenYa-Li Cao
Oct 21, 2019·Cancer Letters·Zhen ZhangXia Li
Dec 8, 2019·Cancers·Changwon YangWhasun Lim
Dec 11, 2019·Cancer Management and Research·Chen PanXiaoling Wu
Jan 19, 2020·Thoracic Cancer·Lin YuJie Song
Mar 15, 2020·Biological Research·Guizhi ZhaoYang Guo
Mar 19, 2020·Cells·Nuzhat AhmedGeorge Kannourakis
Mar 21, 2020·Journal of Biochemistry·Jun ChenYa-Li Cao
Apr 21, 2020·Cancer Treatment Reviews·Tzu-Ting HuangJung-Min Lee