MiR-522 contributes to cell proliferation of human glioblastoma cells by suppressing PHLPP1 expression

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Shubao ZhangYuguang Liu

Abstract

Previous studies have shown that microRNAs play essential roles in cancer growth and progression. Although a number of microRNAs were differentially expressed in glioblastoma (GBM). In this study, we evaluated the miR-522s role in cell proliferation in GBM. Expression of miR-522 is markedly upregulated in GBM tissues and GBM cells compared with the matched non-tumor adjacent brain tissues (TAT) and normal human astrocytes (NHAs). In functional assays, miR-522 promoted GBM cell proliferation, which could be reversed by inhibitor of miR-522. We further identified PH domain leucine-rich repeats protein phosphatase-1 (PHLPP1) as a putative target of miR-522, which is likely a main contributor to the promotion of tumor cell growth observed in our assays. Our results demonstrated that miR-522 promoted tumor cell proliferation and hence may represent a novel therapeutically relevant cellular target to treatment of GBM patients.

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Citations

Mar 11, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Hao ZhangChengyi Sun
Apr 19, 2015·Journal of Ovarian Research·Yingying ZhouTing Shuang
Sep 17, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Zhengqiang WangHonggang Yu
Jun 14, 2019·Journal of Cellular Biochemistry·Xiqiang Xu, Mengmeng Liu
Jul 5, 2019·The Kaohsiung Journal of Medical Sciences·Hong-Chang ZhangChang-Bao Chen
May 22, 2021·Translational Psychiatry·Lawrence Shih-Hsin WuAndrew Tai-Ann Cheng
Oct 4, 2020·Experimental and Molecular Pathology·Omidvar RezaeiSoudeh Ghafouri-Fard

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