May 16, 2015

miR-551a and miR-551b target GLIPR2 and promote tumor growth in High-Risk Head and Neck Cancer by modulating autophagy

BioRxiv : the Preprint Server for Biology
Narasimha Kumar Karanam

Abstract

Distant metastasis (DM) and local-regional recurrence (LR) after radiation and chemo therapy are major cause of treatment failure for patients with head and neck squamous cell carcinoma. However, detailed underlying mechanisms leading to DM and LR in patients are not fully understood yet. MiRNA have been proposed as biomarkers in a variety of biological and medical conditions such as cancer and stress response. The advantages of miRNA as a biomarker lies in its stability in tissues as well as body fluids, hence the potential for non-invasive diagnosis and prognosis. In this study, towards understanding the molecular mechanism causing DM and LR in HN cancer patients we performed miRNA expression profiling using tumor samples from 118 head and neck cancer patients treated by post-operative radiotherapy (PORT) at M.D. Anderson Cancer Center from 1992 to 1999. All patients were considered to be at high-risk for recurrence having histologically proven advanced squamous cell carcinoma. Amongst these samples, 41 found to have distant metastasis (DM), 53 responded without relapse (no evidence of disease (NED)) to PORT. Comparison of miRNA expression between DM and NED specimens using two-way ANOVA identified 28 miRNAs that were differe...Continue Reading

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Mentioned in this Paper

Biological Markers
Neuro-Oncological Ventral Antigen 2
Study
In Vivo
Biological Adaptation to Stress
Neoplasm Recurrence, Local
Transfection
Organic Chemicals
Inhibitors
Neoplasms

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