MiR-572 prompted cell proliferation of human ovarian cancer cells by suppressing PPP2R2C expression

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Ai-Hua WuShi-Ling Chen

Abstract

Ovarian cancer (OC) remains one of the most common types of malignant cancer, and the molecular mechanism underlying its proliferation is still largely unclear. It is reported that microRNAs acted as important regulators of cell proliferation by regulating its targeted gene. In this study, our result showed that miR-572 was markedly upregulated in OC cell lines and clinical tissues. Results of both gain-of-function and loss-of-function experiments revealed that upregulation of miR-572 expression dramatically promoted OC cell proliferation, whereas decreased miR-572 expression significantly reduced cell proliferation. Bioinformatics analysis and luciferase reporter assays further revealed PPP2R2C, a putative tumor suppressor as a potential target of miR-572. Moreover, silencing of PPP2R2C using small interfering RNA (siRNA) counteracted the proliferation arrest by miR-572-in in OC cells. In sum, our data provide that miR-572 promoted cell proliferation in OC by targeting PPP2R2C and might serve as a therapeutic target of OC.

References

May 1, 2012·The British Journal of Dermatology·M SandF G Bechara
Dec 29, 2012·Molecular Cancer Therapeutics·Chuanliang XuYinghao Sun
Mar 16, 2013·Molecular Cancer Research : MCR·Eric G BluemnPeter S Nelson
Sep 4, 2013·International Journal of Cancer. Journal International Du Cancer·Na LiuJun Ma
Nov 23, 2013·Carcinogenesis·Hongchao ZhaoMinhua Zheng
Jul 17, 2014·Trends in Molecular Medicine·Josie HayesSean Lawler
Aug 30, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Hua LiuFeng-Hou Gao
Feb 1, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Ying-Chun Gao, Jie Wu
Apr 16, 2015·Journal of Gynecologic Oncology·Suk Joon Chang, Robert E Bristow
May 8, 2015·Journal of Translational Medicine·Roberta MancusoMario Clerici
May 23, 2015·Obstetrics and Gynecology·Jason D WrightDawn L Hershman
Aug 2, 2015·Journal of Ovarian Research·Ying LiXiaokui Yang

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Citations

Oct 11, 2016·Journal of Immunology Research·Ferah BudakHaluk Barbaros Oral
Aug 15, 2017·Stem Cells and Development·Anastassia SerguienkoElse Munthe
May 20, 2017·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Lei YanJinqiu Gui
Jun 24, 2017·Minerva pediatrica·Zhengwei LiYingchun Shi
Aug 13, 2017·BMC Genomics·Ian H BellayrRaj K Puri
Dec 10, 2019·Epigenomes·Diana L GerrardSeth Frietze
Nov 3, 2020·Non-coding RNA Research·Oscar Raul Fajardo-RamirezIvan Alberto Marino-Martinez

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