miR-577 inhibits glioblastoma tumor growth via the Wnt signaling pathway

Molecular Carcinogenesis
Weiguang ZhangShiguang Zhao

Abstract

microRNAs (miRNAs) are commonly altered in glioblastoma. Publicly available algorithms suggest the Wnt pathway is a potential target of miR-577 and the Wnt pathway is commonly altered in glioblastoma. Glioblastoma has not been previously evaluated for miR-577 expression. Glioblastoma tumors and cell lines were evaluated for their expression of miR-577. Cell lines were transfected with miR-577, miR-577-mutant, or control mimics to evaluate the effect of miR-577 expression on cell proliferation in vitro and in an animal model. Wnt pathway markers were also evaluated for their association with miR-577 expression. miR-577 expression was decreased in 33 of 40 (82.5%) glioblastoma tumors and 5 of 6 glioblastoma cell lines. miR-577 expression correlated negatively with cell growth and cell viability. miR-577 down-regulation was associated with increased expression of the Wnt signaling pathway genes lipoprotein receptor-related protein (LRP) 6 (LRP6) and β-catenin. Western blot analysis confirmed decreased expression of the Wnt signaling pathway genes Axin2, c-myc, and cyclin D1 in miR-577 transfected cells. miR-577 expression is down-regulated in glioblastoma. miR-577 directly targets Wnt signaling pathway components LRP6 and β-cateni...Continue Reading

References

Sep 4, 1998·Science·T C HeK W Kinzler
Dec 2, 1999·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·P J Morin
Nov 7, 2000·Genes, Chromosomes & Cancer·N PaunuH Haapasalo
Mar 11, 2005·The New England Journal of Medicine·Roger StuppUNKNOWN National Cancer Institute of Canada Clinical Trials Group
Oct 15, 2005·Development·Ines Alvarez-Garcia, Eric A Miska
Nov 1, 2005·Nature·Jan KrützfeldtMarkus Stoffel
Mar 25, 2006·Nature Reviews. Cancer·Aurora Esquela-Kerscher, Frank J Slack
Jun 24, 2006·The Oncologist·Jeanine T Grier, Tracy Batchelor
Sep 23, 2006·Developmental Biology·Baohong ZhangTodd A Anderson
Apr 5, 2007·Nature Protocols·Gustavo TiscorniaInder M Verma
May 24, 2007·Cancer·Sith SathornsumeteeJeremy N Rich
Jun 29, 2007·Nature·David Dominguez-SolaRiccardo Dalla-Favera
Aug 2, 2008·The New England Journal of Medicine·Patrick Y Wen, Santosh Kesari
Oct 24, 2008·The New England Journal of Medicine·Bruce R Bistrian
May 9, 2009·Advanced Drug Delivery Reviews·Yu-Kyoung Oh, Tae Gwan Park
Oct 21, 2009·The AAPS Journal·Jeffrey T DeSano, Liang Xu
Oct 23, 2010·Molecular Cell·Anthony K L Leung, Phillip A Sharp
Jul 8, 2011·Nature Reviews. Cancer·Elizabeth A MusgroveRobert L Sutherland
Feb 1, 2012·The Cancer Journal·Kevin P Becker, James Yu
Feb 1, 2012·The Cancer Journal·Ahmed Mohyeldin, Ennio Antonio Chiocca
Mar 29, 2012·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Kailiang ZhangChunsheng Kang
Apr 25, 2012·Neurology Research International·Fumiharu OhkaToshihiko Wakabayashi
Sep 4, 2012·Biochemical and Biophysical Research Communications·Biao YanJin-Liang Zhao
Jul 12, 2013·Nature·Cristina ClaveríaMiguel Torres
Jan 23, 2014·JAMA : the Journal of the American Medical Association·Nicolai A SchultzJulia S Johansen
Jun 7, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Jingwen HuRong Yin

❮ Previous
Next ❯

Citations

Aug 5, 2015·Oncology Reports·Qiang WenQingjie Ma
Jul 30, 2015·Journal of Neuropathology and Experimental Neurology·Ulf D KahlertCharles G Eberhart
Nov 29, 2015·Asian Pacific Journal of Tropical Medicine·Li-Yan WangYong Liu
Jan 24, 2017·Laboratory Investigation; a Journal of Technical Methods and Pathology·Weiguang ZhangDan Zhu
Feb 6, 2017·Journal of Biochemical and Molecular Toxicology·Haiping JiangKan Jie
Dec 19, 2017·Biomedit︠s︡inskai︠a︡ khimii︠a︡·O I KitS B Panina
Jul 20, 2018·Journal of Cellular and Molecular Medicine·Dong-Mei WuYuan-Lin Zheng
Aug 4, 2018·Journal of Neurosurgery·Takuma HaraAkira Matsumura
Sep 5, 2019·The Journal of Gene Medicine·Jian YangShunyu Hou
Feb 1, 2020·Current Pharmaceutical Design·Seyed Hossein ShahcheraghiHamid Reza Sadeghnia
Jul 2, 2019·Molecular Medicine Reports·Jiancun WangGuancheng Hu
Feb 15, 2019·FEBS Open Bio·Zhi-Peng RenXiang-Yang Chu
Feb 12, 2017·BMC Bioinformatics·Claudia CavaIsabella Castiglioni
May 3, 2018·Experimental & Molecular Medicine·Yong WangXiandong Zeng
Jun 27, 2019·Journal of Cellular Biochemistry·Lingyu QiChanggang Sun
Aug 6, 2020·Cancer Management and Research·Yanhong HaoZhibin Zhang
Apr 24, 2020·Molecular Medicine Reports·Jing ZhouHongmei Fu
Oct 19, 2020·Journal of Ovarian Research·Jing XuYang Liu
Jul 2, 2021·Journal of Oncology·Xingqing JiaWujun Xiong
Oct 4, 2020·Experimental and Molecular Pathology·Omidvar RezaeiSoudeh Ghafouri-Fard

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adherens Junctions

An adherens junction is defined as a cell junction whose cytoplasmic face is linked to the actin cytoskeleton. They can appear as bands encircling the cell (zonula adherens) or as spots of attachment to the extracellular matrix (adhesion plaques). Adherens junctions uniquely disassemble in uterine epithelial cells to allow the blastocyst to penetrate between epithelial cells. Discover the latest research on adherens junctions here.

Cadherins and Catenins

Cadherins (named for "calcium-dependent adhesion") are a type of cell adhesion molecule (CAM) that is important in the formation of adherens junctions to bind cells with each other. Catenins are a family of proteins found in complexes with cadherin cell adhesion molecules of animal cells: alpha-catenin can bind to β-catenin and can also bind actin. β-catenin binds the cytoplasmic domain of some cadherins. Discover the latest research on cadherins and catenins here.