miR-598 acts as a tumor suppressor in human gastric cancer by targeting IGF-1R

OncoTargets and Therapy
Na LiuHong Wang

Abstract

In recent years, the aberrant expression of miR-598 in tumorigenesis has been demonstrated, as well as the fact that the IGF-1R pathway is also involved in the development of human gastric cancer (GC). The present study aimed to investigate the molecular mechanisms underlying miR-598-regulated IGF-1R expression in human GC. We analyzed the expression of miR-598 and IGF-1R in GC samples and cells, and evaluated the clinical significance of miR-598 and IGF-1R in GC patients. Furthermore, in vitro and in vivo assays were used to investigate the molecular mechanisms of miR-598 and IGF-1R. miR-598 expression was frequently downregulated in GC tissues and cells, and significantly correlated with poor prognosis, vascular invasion, TNM stage, and lymph node metastases as well as IGF-1R expression. The overexpression of miR-598 obviously inhibited cell proliferation, migration, invasion, and induced cell cycle arrest in the G1/S phase, and increased the apoptosis of GC cells. The overexpression of miR-598 also significantly inhibited ERK1/2 and Akt phosphorylation level. In vivo assay validated the inhibitory effect of miR-598 on tumor growth. Further studies showed that miR-598 inhibited IGF-1R protein expression by directly targeting ...Continue Reading

Citations

Mar 27, 2021·Frontiers in Cell and Developmental Biology·Soudeh Ghafouri-FardMohammad Taheri
Dec 4, 2020·Clinics and Research in Hepatology and Gastroenterology·Junfeng LuZhongsong Zhao
Jun 29, 2021·Heliyon·André Eduardo de Almeida FranzoiMarcus Vinicius Magno Gonçalves

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Datasets Mentioned

BETA
GES-1

Methods Mentioned

BETA
transfection
Assay
flow cytometry
scraping

Software Mentioned

TargetScan
miRanda
CellQuest

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