miR-615 Fine-Tunes Growth and Development and Has a Role in Cancer and in Neural Repair

Cells
Marisol Godínez-Rubí, Daniel Ortuño-Sahagún

Abstract

MicroRNAs (miRNAs) are small noncoding RNAs that function as epigenetic modulators regulating almost any gene expression. Similarly, other noncoding RNAs, as well as epigenetic modifications, can regulate miRNAs. This reciprocal interaction forms a miRNA-epigenetic feedback loop, the deregulation of which affects physiological processes and contributes to a great diversity of diseases. In the present review, we focus on miR-615, a miRNA highly conserved across eutherian mammals. It is involved not only during embryogenesis in the regulation of growth and development, for instance during osteogenesis and angiogenesis, but also in the regulation of cell growth and the proliferation and migration of cells, acting as a tumor suppressor or tumor promoter. It therefore serves as a biomarker for several types of cancer, and recently has also been found to be involved in reparative processes and neural repair. In addition, we present the pleiad of functions in which miR-615 is involved, as well as their multiple target genes and the multiple regulatory molecules involved in its own expression. We do this by introducing in a comprehensible way the reported knowledge of their actions and interactions and proposing an integral view of its...Continue Reading

References

Oct 1, 1975·Zeitschrift Für Klinische Chemie Und Klinische Biochemie·A A El-Aaser, M M El-Merzabani
Dec 19, 1995·Proceedings of the National Academy of Sciences of the United States of America·H W SharmaR Narayanan
Jan 3, 2008·PloS One·Joost M Woltering, Antony J Durston
Jan 17, 2008·Nature Reviews. Genetics·Witold FilipowiczNahum Sonenberg
Mar 25, 2009·Journal of Translational Medicine·Jiaqiang RenDavid F Stroncek
Nov 3, 2009·Documenta Ophthalmologica. Advances in Ophthalmology·Elsa Kermorvant-DucheminSylvain Chemtob
Jul 16, 2010·Nature Reviews. Genetics·Roger P AlexanderMark B Gerstein
Jan 5, 2011·Nucleic Acids Research·Koray D KayaOzlen Konu
Aug 2, 2011·Cell·Leonardo SalmenaPier Paolo Pandolfi
Aug 9, 2011·Nature Reviews. Cancer·Marieke van KouwenhoveReuven Agami
Feb 19, 2013·Journal of Cataract and Refractive Surgery·David HessertMyah Mirzaoff
Jun 27, 2013·Wiley Interdisciplinary Reviews. Developmental Biology·Peter W H Holland
Jul 5, 2013·PloS One·Kristina ScheeKjersti Flatmark
Jul 9, 2013·Essays in Biochemistry·Tamas Dalmay
Oct 15, 2014·PloS One·Yasuhiro MiyamotoHarmeet Malhi
Mar 27, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Sercan Ergun, Serdar Oztuzcu
May 20, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Li-Jie SongLiu-Xing Wang
Aug 14, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yuanyuan JiangJinping Zhang
Sep 26, 2015·Cancer Biomarkers : Section a of Disease Markers·Zaki Abu RabiDragica Nikolić-Vukosavljević
Dec 15, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Xiaoyu WuGui Liang
Mar 5, 2016·Oncotarget·Hairong LiuYin-Yuan Mo
May 4, 2016·Perspectives in Clinical Research·Ajay Francis ChristopherParveen Bansal
Jul 5, 2016·Briefings in Bioinformatics·Giuseppe MilitelloShizuka Uchida
Nov 30, 2016·Genes & Development·Natalia SacilottoSarah De Val
Jan 12, 2017·Nucleic Acids Research·Laura CastelliniAmato J Giaccia
Jul 19, 2017·Nature Communications·Martin TeichertHellmut G Augustin
Sep 2, 2017·Genes & Development·Jacqueline Deschamps, Denis Duboule
Oct 4, 2017·Oncotarget·Meijun DuLiang Wang
Nov 29, 2017·Cancer Research·Xin YangJianyuan Luo
Dec 12, 2017·Seminars in Diagnostic Pathology·Edward B Stelow, Hadi Yaziji
Mar 5, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Jizhao WangJia Zhang
Mar 23, 2018·Oncology Research·Jiangtao LiuGongwen Zhang
Apr 2, 2018·Biochemical and Biophysical Research Communications·Yanwei JiHaoran Hu
Jun 29, 2018·Angiogenesis·Marchien G DallingaReinier O Schlingemann
Sep 19, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yuchen SunXiaozhi Zhang
Dec 18, 2018·European Review for Medical and Pharmacological Sciences·Z-H PanS-X Luo
Mar 16, 2019·Frontiers in Immunology·Naeun LeeWan-Uk Kim
Nov 20, 2019·Genes·Kallayanee Chawengsaksophak
Apr 3, 2020·Cellular and Molecular Life Sciences : CMLS·Céline S GonçalvesBruno M Costa
Apr 5, 2020·Cells·Simoneide S Titze-de-AlmeidaRicardo Titze-de-Almeida
Apr 28, 2020·Journal of Experimental & Clinical Cancer Research : CR·Bo LeiYiwen Li
May 14, 2020·Clinical and Experimental Medicine·Ilgiz GareevShiguang Zhao

Related Concepts

Biological Markers
Malignant Neoplasms
Embryonic Development
Gene Expression
Genes
Neurons
Osteogenesis
Physiological Processes
RNA
Tumor Promoters

Related Feeds

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Cell Migration in Cancer and Metastasis

Migration of cancer cells into surrounding tissue and the vasculature is an initial step in tumor metastasis. Discover the latest research on cell migration in cancer and metastasis here.