MiR-622 inhibited colorectal cancer occurrence and metastasis by suppressing K-Ras

Molecular Carcinogenesis
Yantian FangJianbin Xiang

Abstract

Colorectal cancer (CRC) is one of the leading causes of cancer death worldwide, with many oncogenes and anti-oncogenes involved. MicroRNAs (miRNAs) are a class of small, noncoding RNA molecules that can adjust downstream targets. Accumulating evidence has revealed that microRNAs govern the occurrence and development of cancer. Here, we studied the role of miR-622 in CRC and clarified the underlying mechanism. We detected that miR-622 was down-regulated in colorectal tumor tissues and cell lines and that miR-622 was lower in metastatic CRC tissues compared with that in non-metastatic specimens. Furthermore, we confirmed that miR-622 inhibited tumor proliferation and migration in vitro. Through dual-luciferase reporter assay, we found kirsten rat sarcoma (K-Ras) gene was the direct target of miR-622. More importantly, K-Ras overexpression can rescue the inhibitory effect of miR-622 on CRC development. All these data were validated in colon xenograft tumor model. MiR-622-K-Ras signal pathway was a potentially new direction in the development of screening target and therapeutic treatments for CRC. © 2015 Wiley Periodicals, Inc.

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Citations

Apr 28, 2017·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Sang Wook Kim
Aug 11, 2017·Journal of Cellular Biochemistry·Jin XuWeixing Hu
Apr 4, 2019·Artificial Cells, Nanomedicine, and Biotechnology·Jingzhe ZhangWenjun Wang
May 28, 2019·Journal of Cellular Physiology·Alireza AnvarniaDariush Shanehbandi
Sep 13, 2019·Journal of Cellular Biochemistry·Atena SoleimaniSeyed Mahdi Hassanian
Apr 2, 2019·Melanoma Research·Lauge H MikkelsenSteffen Heegaard
Feb 20, 2020·Inflammatory Bowel Diseases·Daisuke OkamotoAtsushi Masamune
Apr 9, 2020·Vaccines·Stefania ScalaElena Monica Borroni
Dec 20, 2019·Artificial Cells, Nanomedicine, and Biotechnology·Yan ZhangZhi Lan
Dec 29, 2020·Technology in Cancer Research & Treatment·Chuan ChengJianping Wang
Feb 20, 2021·Frontiers in Microbiology·Ying ZhaoXueqin Ni
Jun 30, 2021·Journal of Biological Research·Jingpeng WangHuihua Han
Aug 24, 2021·Gastroenterology Research and Practice·Huixia LiJianping Wang

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