miR-630 overexpression in hepatocellular carcinoma tissues is positively correlated with alpha-fetoprotein

Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
Jian-wen ZhangNan Jiang

Abstract

MicroRNA-630 (miR-630) has been shown to be involved in various human malignancies. However, its role in hepatocellular carcinoma (HCC) remains unknown. TaqMan qRT-PCR assay was performed to detect the expression of miR-630 in 42 pairs of HCC tissues and corresponding noncancerous hepatocellular tissues, and its correlations with clinicopathologic features and serum alpha-fetoprotein (AFP) level of patients were analyzed. The present study found that miR-630 expression was significantly increased in HCC tissues and cells compared with their normal counterparts. miR-630 expression level did not significantly chang at stage I but was markedly increased at advanced TNM stage (stage II~III). In addition, the increased expression of miR-630 in tissues of HCC appeared in patients who exhibited elevated serum levels of AFP (>25 ng/ml), but not in those with normal AFP levels (≤25 ng/ml). The miR-630 expression in carcinoma tissues revealed a positive correlation with the levels of serum alpha-fetoprotein (AFP; R2=0.768). These results suggest that miR-630 is associated with tumor progression of hepatocellular carcinoma and may be a potential prognosis indicator.

References

Jun 10, 2008·Clinica Chimica Acta; International Journal of Clinical Chemistry·Evi N Debruyne, Joris R Delanghe
Jan 28, 2010·Gastroenterology·Sara ToffaninJosep M Llovet
Feb 11, 2010·Cancer Research·Lorenzo GalluzziGuido Kroemer
Feb 23, 2010·Seminars in Liver Disease·Sandrine ImbeaudJessica Zucman-Rossi
Jan 29, 2011·Cell Death and Differentiation·Y HuangE Ratovitski
Feb 8, 2011·CA: a Cancer Journal for Clinicians·Ahmedin JemalDavid Forman
Apr 12, 2011·Journal of Cancer·Sidney W FuYan-Gao Man
Jun 2, 2012·The Lancet Oncology·Yi W KongMartin Bushell
Feb 26, 2013·The Journal of Clinical Investigation·Tsang-Chih KuoMin-Liang Kuo
Jul 3, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Rongrong WeiHui-Yun Wang
Sep 6, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Li WangDengfu Yao
Sep 7, 2013·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Naota TauraKazuhiko Nakao
Oct 2, 2013·Annual Review of Pathology·Gianpiero Di LevaCarlo M Croce
Nov 30, 2013·Genomics, Proteomics & Bioinformatics·Mahmoud ElHefnawiMarwa Amer
May 13, 2014·Drug Discoveries & Therapeutics·Jiwei Huang, Yong Zeng
Jul 2, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Dake ChuGang Ji
Aug 19, 2014·The American Journal of Case Reports·Abdel-Naser ElzoukiOmer Ismail
Sep 25, 2015·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Jerzy P SzaflarskiChristopher J Lindsell

❮ Previous
Next ❯

Citations

Oct 7, 2015·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Gangli YanHongyu Yu
Oct 30, 2019·Cellular and Molecular Life Sciences : CMLS·Rong LiWenrong Xu
Nov 26, 2015·Oncotarget·Ci-Xiang ZhouQian Zhao
Aug 28, 2016·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Shuhong ZhangShuhong Zhang
Feb 17, 2017·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Bin SunZheng Huang
Mar 9, 2021·Frontiers in Oncology·Dhanya KalathilAsha S Nair

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR
ELISA
surgical resection

Software Mentioned

SPSS

Related Concepts

Related Feeds

Carcinoma, Hepatocellular

Hepatocellular Carcinoma is a malignant cancer in liver epithelial cells. Discover the latest research on Hepatocellular Carcinoma here.