MiR-873 acts as a novel sensitizer of glioma cells to cisplatin by targeting Bcl-2

International Journal of Oncology
Xiong ChenXiaohua He

Abstract

Treatment with cisplatin, a chemotherapeutic agent commonly used in glioma patients, often results in chemoresistance. Increasing evidence has shown that microRNAs (miRNAs) are implicated in the drug resistance of gliomas. However, the function of miR‑873 in cisplatin resistance of gliomas remains unknown. In this study, we found that many miRNAs, including miR‑873, are differentially expressed in cisplatin-resistant glioma cells compared to wild-type glioma cells. Moreover, cisplatin reduced the expression of miR‑873 in a time-dependent manner. Overexpression of miR‑873 decreased the cell proliferation, migration and invasion while increased apoptosis of cisplatin-resistant glioma cells and sensitized the cells to cisplatin-induced cell growth arrest and apoptosis. Furthermore, miR‑873 was downregulated while Bcl-2 was upregulated in the tissues of twelve high-grade glioma patients compared to seven normal brain tissues, and the miR‑873 level was negatively correlated with the Bcl-2 protein level. A luciferase reporter assay further confirmed that Bcl-2 was a direct target of miR‑873, and miR‑873 decreased the level of the Bcl-2 protein in cisplatin-resistant glioma cells. Notably, re-expression of Bcl-2 attenuated the functio...Continue Reading

References

Dec 9, 2004·Journal of Neurochemistry·Wolfgang WickMichael Weller
Dec 3, 2008·Biological Reviews of the Cambridge Philosophical Society·Niamh Lynam-LennonJohn V Reynolds
Feb 23, 2010·Genomics, Proteomics & Bioinformatics·Yimei CaiJun Yu
Sep 23, 2011·Neuro-oncology·Alexander BaraniskinRoland Schroers
Apr 5, 2013·CNS Neuroscience & Therapeutics·Rui-Yan LiChuan-Lu Jiang
Apr 23, 2013·Biochemical and Biophysical Research Communications·Fang WangDaiming Fan
Jun 29, 2013·Journal of Experimental & Clinical Cancer Research : CR·Yong GuoFenghua Chen
Aug 21, 2014·Journal of Neuro-oncology·Wanghao ChenQiaoyu Li
Feb 20, 2015·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Santosh PatnaikSamjot Singh Dhillon
Apr 8, 2015·International Journal of Oncology·Kui LiuXiaochun Sun

❮ Previous
Next ❯

Citations

Mar 10, 2017·Genes·Duncan Ayers, Jo Vandesompele
Feb 15, 2020·Artificial Cells, Nanomedicine, and Biotechnology·Zheng RenDesheng Yang
Feb 7, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Di-di WuZhi-Hong Zong
Dec 2, 2018·Frontiers in Molecular Neuroscience·Lanlan ZangXueyuan Heng
Apr 9, 2020·Frontiers in Pharmacology·Jiabei ZhouLushan Yu
Mar 1, 2019·Non-coding RNA·Jakub GodlewskiElzbieta Salinska
Jun 11, 2016·Cancer Medicine·Amanda SheaDeepak Kumar
Sep 14, 2018·Frontiers in Oncology·Fabio CorràStefano Volinia
Sep 18, 2018·Molecular Medicine Reports·Chuan-Gang ZhangXia Wu
Dec 14, 2017·International Journal of Genomics·Barbara BanelliMassimo Romani
Jan 11, 2021·Experimental and Molecular Pathology·Mohammad TaheriMarcel E Dinger
Jan 18, 2019·Molecular Therapy. Nucleic Acids·Hamada A MokhlisBulent Ozpolat
Sep 20, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Metin ÇalışkanVildan Bozok Çetintaş
Apr 14, 2019·Trends in Pharmacological Sciences·Hélène LajousEmmanuel Garcion
Jun 3, 2021·International Journal of Molecular Sciences·Jaewan JeonHae Yu Kim
Jul 18, 2021·Molecular and Cellular Biochemistry·Ahmad MovahedpourMortaza Taheri-Anganeh
Jun 12, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yuqiang LiangBaolan Lu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

BCL-2 Family Proteins

BLC-2 family proteins are a group that share the same homologous BH domain. They play many different roles including pro-survival signals, mitochondria-mediated apoptosis and removal or damaged cells. They are often regulated by phosphorylation, affecting their catalytic activity. Here is the latest research on BCL-2 family proteins.

Related Papers

Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban
Yu-Mei RaoCai-Hong Chen
© 2021 Meta ULC. All rights reserved