miR-944 inhibits cell migration and invasion by targeting MACC1 in colorectal cancer

Oncology Reports
Li-Qiang WenFanghai Han

Abstract

Dysfunction of microRNAs (miRNAs) is strongly proved to participate in the pathogenesis and tumorigenicity of colorectal cancer (CRC). miR-944 was reported to play either oncogenic or tumor suppressive roles in human cancers. A recent study reported that the levels of miR-944 in recurrent CRC patients were evidently lower than that in non-recurrent cases, suggesting that miR-944 may function as a tumor suppressive miRNA in CRC. Yet, the clinical value and biological function of miR-944 remain rarely known in CRC. In the present study, we present that miR-944 level in CRC tissues is notably reduced compared to matched non-cancerous specimens. Its decreased level is evidently correlated with malignant clinical parameters and poor prognosis of CRC patients. Accordingly, the levels of miR-944 were obviously downregulated in CRC cells. Ectopic expression of miR-944 in CRC cells prominently inhibits the migration and invasion of tumor cells, while miR-944 knockdown increased these effects of CRC cells. Mechanically, miR-944 negatively regulated the metastasis-associated in colon cancer-1 (MACC1) abundance in CRC cells. Herein, MACC1 was found to be a downstream molecule of miR-944 in CRC. An inversely correlation between miR-944 and ...Continue Reading

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Citations

May 9, 2018·Angiogenesis·Anna Janaszak-JasieckaRafal Bartoszewski
Sep 4, 2018·The Kaohsiung Journal of Medical Sciences·Zi-Yu NiuXiang-Jun Xie
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Nov 3, 2021·Human Genetics·Abhishek BardhanAmlan Ghosh

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