miR‑205 targets YAP1 and inhibits proliferation and invasion in thyroid cancer cells.

Molecular Medicine Reports
Dewei LiShuilong Zhang

Abstract

MicroRNA‑205 (miR‑205) has been reported to be downregulated, and serves critical roles in the pathogenesis and progression of several types of cancer, including breast, prostate and lung cancer. However, the underlying mechanism of miR‑205 in thyroid cancer remains unclear. In the present study, it was demonstrated that the expression of miR‑205 was reduced in thyroid cancer tissues compared with non‑cancer tissues. In addition, miR‑205‑knockdown models in the BHT‑101 cell line and ectopic expression models in the 8505‑C cell line were used to measure the biological functions of miR‑205. The results indicated that miR‑205 inhibited certain aspects of thyroid cancer, including cell proliferation, migration and invasion. Furthermore, Yes‑associated protein 1 (YAP1) was identified as a target gene of miR‑205 and its expression was negatively correlated with that of miR‑205 in thyroid cancer tissues. Depletion of YAP1 partially reduced the anti‑miR‑205‑induced cell growth and invasion. The results of the present study suggested that the tumor suppressive functions of miR‑205 via targeting YAP1 could be a novel target for the treatment of thyroid cancer.

References

Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Jan 31, 2009·The American Journal of Pathology·Geoffrey ChildsNicolas F Schlecht
Mar 11, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Danit LebanonyMahesh Mansukhani
Oct 19, 2010·Developmental Cell·Duojia Pan
Feb 22, 2012·EMBO Molecular Medicine·Marilena V Iorio, Carlo M Croce
Apr 20, 2012·PloS One·Mihriban KaraayvazJingfang Ju
May 15, 2012·Molecular Oncology·Claudia PiovanCarlo M Croce
Jan 11, 2013·Thyroid : Official Journal of the American Thyroid Association·Valeria CarinaCarla Giordano
Feb 26, 2013·Thyroid : Official Journal of the American Thyroid Association·Kazuaki YasuiYuji Nagayama
May 21, 2013·Experimental and Molecular Pathology·Jena HudsonRebecca D Chernock
Jun 15, 2013·Endocrine-related Cancer·Xiaoli LiuMingzhao Xing
Nov 20, 2013·Nature Reviews. Endocrinology·Pierlorenzo PallanteAlfredo Fusco
Dec 18, 2013·Neoplasia : an International Journal for Oncology Research·Tao ZhangXiaodong Zhang
Jan 21, 2014·Journal of Molecular Endocrinology·Matthias S DettmerMarina N Nikiforova
Jun 24, 2014·Current Genomics·Salvatore Benvenga, Christian A Koch
Sep 16, 2014·International Journal of Cancer. Journal International Du Cancer·Jacques FerlayFreddie Bray
Mar 6, 2015·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Shumei SongJaffer A Ajani
Jun 23, 2015·Cell Biochemistry and Function·Chang-Jiang LeiGang Zheng
Aug 13, 2015·ELife·Vikram AgarwalDavid P Bartel
Jan 9, 2016·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
Feb 16, 2016·The Journal of Clinical Investigation·Iñigo LandaJames A Fagin
Mar 11, 2016·Journal of Cancer Research and Clinical Oncology·Alexander I DamanakisPietro Di Fazio

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