miR‑338‑3p suppresses tumor growth of ovarian epithelial carcinoma by targeting Runx2.

International Journal of Oncology
Chunyan WenHaifeng Li

Abstract

miR‑338‑3p, a recently discovered miRNA, has been shown to play important roles in tumorigenesis and metastasis in various cancers. However, the exact roles and mechanisms of miR‑338‑3p remain unknown in human ovarian epithelial carcinoma (EOC). The relationship between miR‑338‑3p expression pattern and clinicopathological features of patients with EOC were determined by real-time quantitative RT-PCR. Furthermore, the role of miR‑338‑3p and possible molecular mechanisms in EOC was investigated by several in vitro approaches and in a nude mouse model. We first showed that the expression of miR‑338‑3p was significantly downregulated in EOC tissues compared to those in adjacent normal tissues, and the value was negatively related to advanced FIGO stage, high histological grading and lymph node metastasis (P<0.01). An in vitro analysis revealed that the overexpression of miR‑338‑3p in EOC cells significantly inhibited cell proliferation, colony formation, migration and invasion, inducing cell apoptosis and enhancing caspase-3, -8, and -9 activities. Bioinformatic analysis and dual luciferase assays identified Runx2 as a direct target of miR‑338‑3p. We also found that enforced expression of miR‑338‑3p markedly inhibited the in vivo ...Continue Reading

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Citations

Jul 14, 2017·Cell Death & Disease·Yingchun LiangQinong Ye
Mar 25, 2019·Experimental and Therapeutic Medicine·Mingliang LuYan Fu
Aug 8, 2015·International Journal of Oncology·Ying JinQingjie Ma
Apr 11, 2017·International Journal of Oncology·Carlos Palma FloresCésar López-Camarillo
Dec 5, 2017·Experimental and Therapeutic Medicine·Zhigang TongLixin Wang
Dec 18, 2019·Journal of Experimental & Clinical Cancer Research : CR·Ruitao ZhangMinghui Zhang
Oct 1, 2020·International Journal of Molecular Sciences·Vu Hong Loan NguyenChun Peng
May 11, 2018·Cell Death & Disease·Feng SunWenxian Guan
Jan 10, 2021·Life Sciences·Sepideh MirzaeiMichael R Hamblin
Apr 9, 2021·Cellular & Molecular Biology Letters·Meysam Moghbeli
Jul 11, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Qian YiWeichao Sun

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