MiRNA-206 inhibits hepatocellular carcinoma cell proliferation and migration but promotes apoptosis by modulating cMET expression

Acta Biochimica Et Biophysica Sinica
Yuanxi WangYi Gao

Abstract

A close relationship between cancer progression and microRNAs (miRNAs) regulation has been demonstrated. Abnormal microRNA-206 (miR-206) expression has been shown to be related to the development of malignancies. However, the role of miR-206 in hepatocellular carcinoma (HCC) remains unclear. Here, we evaluated the function of miR-206 in HCC. Results showed that miR-206 expression was decreased in 27 human HCC tissues compared with that of adjacent normal tissues. Conversely, cMET was up-regulated in human HCC cancer tissues, and cMET levels were shown to be negatively correlated with miR-206 expression. Abnormally increased miR-206 expression in three HCC cell lines (SMMC-7721, HepG2, and Huh7) attenuated cell viability, migration, and invasion. Increased apoptosis was also observed in these miR-206 expressing cells. Furthermore, we identified that miR-206 targets the 3'-UTR of the cMET gene for silencing, and restoration of cMET expression reversed the inhibitory effect of miR-206 on HCC. Tumor cells expressing miR-206 also showed delayed growth in the in vivo experiments compared with the controls. Altogether, our findings provide new insights into the molecular mechanisms of HCC oncogenesis.

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Citations

Oct 28, 2019·Combinatorial Chemistry & High Throughput Screening·Guobo DuBangxian Tan
Feb 23, 2020·Frontiers in Cell and Developmental Biology·Xin LiuZujiang Yu
Oct 24, 2019·International Journal of Molecular Sciences·Po-Shuan HuangKwang-Huei Lin
Mar 29, 2020·Frontiers in Cell and Developmental Biology·Hong ZhanJun Lin
May 29, 2021·Laboratory Investigation; a Journal of Technical Methods and Pathology·Xin WangLi-Jie Qin
Oct 21, 2020·Biomedical Journal·Po-Shuan HuangKwang-Huei Lin
Jul 2, 2021·Journal of Oncology·Xingqing JiaWujun Xiong
Aug 18, 2020·Mechanisms of Development·Yingjie WangYa-Ni Zhang

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