miRNA-29a in systemic sclerosis: A valid target.

Autoimmunity
Steven O'Reilly

Abstract

Systemic sclerosis is an autoimmune disease that contains an interplay between inflammation and fibrosis. The ultimate effector cell is the myofibroblast that secretes excessive matrix molecules leading to fibrosis. There is no treatment that modifies the disease and this is an unmet clinical need. In this issue of Autoimmunity, Jafarinejad-Farsaangi et al., demonstrate that restitution of microRNA-29a targets the apoptosis rheostat and leads to apoptosis in dermal fibroblasts, suggesting that in vivo targeting of the microRNA through mimics would lead to depletion of the fibroblasts.

Citations

Jun 7, 2017·Biomedical Reports·Duygu HarmanciGul Guner Akdogan
May 3, 2019·Expert Review of Clinical Immunology·Maurizio CutoloVanessa Smith
Oct 30, 2020·Dose-response : a Publication of International Hormesis Society·Xi YangZhengfei Zhu

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Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

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