miRNA and cholesterol homeostasis

Biochimica Et Biophysica Acta
Tae-Il Jeon, Timothy F Osborne

Abstract

MicroRNAs (miRNAs) have recently emerged as a novel class of epigenetic regulators of gene expression. They are systemically involved in the control of lipid metabolism through a complex interactive mechanism that involves gene regulatory networks. Hence, they can contribute to defective lipid metabolism and metabolic diseases. Here, we review recent advances in the roles of lipid-sensing transcription factors in regulating miRNA gene networks, as well as miRNA expression and function in the regulation of cholesterol metabolism. This article is part of a Special Issue entitled: MicroRNAs and lipid/energy metabolism and related diseases edited by Carlos Fernández-Hernando and Yajaira Suárez.

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Citations

Jul 12, 2016·Biochimica Et Biophysica Acta·Yajaira Suárez, Carlos Fernández-Hernando
Sep 24, 2016·Clinical Science·Ugo Soffientini, Annette Graham

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