Mirna Expression in Bladder Cancer and Their Potential Role in Clinical Practice

Current Drug Metabolism
Ana BlancaAntonio Lopez-Beltran

Abstract

To date more than 3000 miRNA sequences have been described in humans and registered at miRBase since their discovery. However, the functions of only a few of these miRNAs have been experimentally determined using deep sequencing technology. Aberrant miRNA expression has been associated with differentiation, invasion and metastasis in several cancers. In this context, recent reports have suggested that miRNAs play important roles in the regulation of target genes by binding to complementary regions of messenger transcripts to repress their translation or regulate degradation. In addition, the expression profiles of certain miRNAs can function biologically as oncogenes and tumor suppressor genes. In this review, we summarize the relationship between miRNAs expression and Bladder Cancer (BC). A comprehensive review of the literature has shown a differential expression between malignant and normal tissues, and that miRNAs could be the driving molecules of the BC progression. Similarly, the expression levels of miRNAs in urine and blood samples of BC patients have been demonstrated to be different from healthy people, a finding that might have diagnostic value. In conclusion, the understanding of miRNAs mechanisms and cell distribut...Continue Reading

Citations

Jun 25, 2019·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Ana BlancaAntonio Lopez-Beltran
Dec 5, 2019·Expert Review of Molecular Diagnostics·Antonio Lopez-BeltranRodolfo Montironi
Oct 16, 2019·The Journal of Pharmacy and Pharmacology·Zhicong ZengYinzhi Song
Jan 7, 2021·Cancers·Antonio Lopez-BeltranRodolfo Montironi
Mar 26, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Pengfeng GongXiaozhou He
Sep 18, 2020·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Ritika KapoorJoanne Su-Yin Yoong
Jan 4, 2022·Critical Reviews in Food Science and Nutrition·Amirhossein SheidaHamed Mirzaei

❮ Previous
Next ❯

Related Concepts

Related Feeds

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Related Papers

Investigative and Clinical Urology
Hideki EnokidaMasayuki Nakagawa
Best Practice & Research. Clinical Endocrinology & Metabolism
Myriem BoufraqechElectron Kebebew
Scandinavian Journal of Clinical and Laboratory Investigation. Supplementum
Gloria BertoliIsabella Castiglioni
Biological Reviews of the Cambridge Philosophical Society
Jen N GohAlan P Kumar
Molecular and Clinical Oncology
Ganghua YangLin Wang
© 2022 Meta ULC. All rights reserved