miRNA expression profile of mucoepidermoid carcinoma

Oral Diseases
N O BinmadiI Alevizos

Abstract

MicroRNAs (miRNAs) are single-stranded RNAs that have been implicated in cancer initiation and progression and act as tumour suppressors or oncogenes. In this study, miRNA profiling was conducted on the most frequent malignancy of salivary glands, mucoepidermoid carcinoma (MEC), in comparison with normal tissues. The TaqMan Human miRNA Cards Array was used for the miRNA profiling of MEC and normal tissues. To validate the differentially expressed miRNAs in MEC, we used real-time PCR (qRT-PCR). miR-302a was the most significantly increased miRNA in cancer tissues (p < .05). Here, we demonstrate that the upregulation of miR-302a expression in SGT cell lines induced cancer cell invasion in vitro. These promising results suggest the need for further studies to establish mir-302a as a marker of invasion and aggressiveness in MEC.

References

Dec 11, 1999·Nucleic Acids Research·M Kanehisa, S Goto
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Aug 29, 2007·The American Journal of Pathology·Wenyong ZhangWayne Tam
Oct 29, 2008·Genome Research·Robin C FriedmanDavid P Bartel
Oct 30, 2008·Nucleic Acids Research·Giorgos L PapadopoulosArtemis G Hatzigeorgiou
May 14, 2009·Bioinformatics·G L PapadopoulosA G Hatzigeorgiou
Nov 4, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Marilena V Iorio, Carlo M Croce
May 25, 2010·Epigenomics·Fabricio F CostaMary J C Hendrix
Nov 5, 2011·BMC Systems Biology·Sebastian SchmeierVladimir B Bajic
Jan 19, 2012·The American Journal of Pathology·Nada O BinmadiJohn R Basile
Apr 29, 2014·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Andrés Coca-PelazAlfio Ferlito
Jul 6, 2014·Molecular Biology Reports·Gabriel Gallo-OllerJavier S Castresana
Aug 7, 2014·Clinical and Translational Medicine·Joseph W O'Connor, Esther W Gomez

❮ Previous
Next ❯

Citations

Aug 8, 2019·Artificial Cells, Nanomedicine, and Biotechnology·Chongmin RenBin Yue
Dec 13, 2019·Oral Diseases·Erison S Dos SantosAdriana F Paes Leme
Jan 21, 2020·Cancer Science·Jiajia LiuXin Jin
Oct 4, 2019·Oncology Letters·Chuan Fang, Yadong Li
Aug 14, 2020·Acta Biochimica Et Biophysica Sinica·Menghuan GuoHong Zhang
Jul 3, 2021·International Journal of Molecular Sciences·Adriana FodorAngela Cozma

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
M OsakiT Ochiya
Rivista di anatomia patologica e di oncologia
L PERONI
© 2022 Meta ULC. All rights reserved