miRNA in a multiomic context for diagnosis, treatment monitoring and personalized management of metastatic breast cancer

Future Oncology
Pavol ZuborOlga Golubnitschaja

Abstract

Metastatic breast cancer is characterized by aggressive spreading to distant organs. Despite huge multilevel research, there are still several important challenges that have to be clarified in the management of this disease. Therefore, recent investigations have implemented a modern, multiomic approach with the aim of identifying specific biomarkers for not only early detection but also to predict treatment responses and metastatic spread. Specific attention is paid to short miRNAs, which regulate gene expression at the post-transcriptional level. Aberrant miRNA expression could initiate cancer development, cell proliferation, invasion, migration, metastatic spread or drug resistance. An miRNA signature is, therefore, believed to be a promising biomarker and prediction tool that could be utilized in all phases of carcinogenesis. This article offers comprehensive information about miRNA profiles useful for diagnostic and treatment purposes that may sufficiently advance breast cancer management and improve individual outcomes in the near future.

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Citations

May 28, 2019·Journal of Cancer Research and Clinical Oncology·Marek SamecDietrich Büsselberg
Jul 28, 2020·Clinical and Experimental Medicine·Chunyu Cao, Changjiang Wang
Dec 1, 2019·Biomolecules·Tala M Abu SamaanDietrich Büsselberg
May 15, 2021·Drug Delivery and Translational Research·Fahima Danesh PouyaMohadeseh Nemati
Jun 23, 2021·Drug Research·Sushmita SrivastavaAsad Ali
Aug 31, 2021·Molecular Therapy. Nucleic Acids·Hyun Jeong SeokIn Hwa Bae

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Methods Mentioned

BETA
GTPase
PCR
antisense oligonucleotides
transfecting
biopsy

Software Mentioned

MOBCdb
miRNA
DIANA
Multi
Inforna
map
miRanda
PicTar
Omics
miRWalk

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