miRNA Influences in NRF2 Pathway Interactions within Cancer Models

Journal of Nucleic Acids
Duncan AyersTherese Hunter

Abstract

The NRF2 transcription factor (nuclear factor-erythroid 2 p45-related factor 2) has been identified as a key molecular player in orchestrating adaptive cellular interactions following a wide spectrum of cellular stress conditions that could be either extracellular or intracellular. Dysregulation of the NRF2 system is implicated in various disease states, including inflammatory conditions. The NRF2 transcription factor is also known to permit cross talk with several other essential cellular signaling pathways. Recent literature has also elucidated the potential influences of miRNA activity over modulations of the NRF2 signalling network. Consequently, further delving into the knowledge regarding the extent of miRNA-induced epigenetic gene regulatory control on key elements of the NRF2 signalling pathway and its cross talk, particularly within the context of cancer models, can prove to be of high clinical importance. This is so since such miRNAs, once identified and validated, can be potentially exploited as novel drug targets for emerging translational medicine-based therapies.

References

Jun 3, 2000·Annual Review of Pharmacology and Toxicology·Y Z GuC A Bradfield
Dec 30, 2003·Genes, Chromosomes & Cancer·Markus MetzlerArndt Borkhardt
Jul 3, 2007·Carcinogenesis·Katsuyuki IidaMasayuki Yamamoto
Nov 10, 2007·Nucleic Acids Research·Sam Griffiths-JonesAnton J Enright
Apr 7, 2010·Antioxidants & Redox Signaling·Nobunao WakabayashiThomas W Kensler
Jul 16, 2010·Science Signaling·Nobunao WakabayashiThomas W Kensler
Aug 26, 2010·Cancer Science·Hirotaka Osada, Takashi Takahashi
Sep 23, 2010·BMC Cancer·Aoife J LoweryMichael J Kerin
Jun 4, 2011·Breast Cancer Research and Treatment·Muhua YangQun Zhou
Jun 23, 2011·Journal of Cellular and Molecular Medicine·Anika Eva WagnerGerald Rimbach
Sep 20, 2011·The Journal of Biological Chemistry·Gabriel EadesQun Zhou
Mar 1, 2012·Vascular Pharmacology·Agnieszka LobodaJozef Dulak
May 15, 2012·Nucleic Acids Research·Brian N ChorleyDouglas A Bell
Dec 6, 2012·Journal of Drug Delivery·Duncan Ayers, Alessandro Nasti
Dec 12, 2012·Biochemical Pharmacology·Holly K BryanB Kevin Park
Mar 16, 2013·Carcinogenesis·Bhupendra SinghHari K Bhat
May 28, 2013·Oxidative Medicine and Cellular Longevity·Dénes TüreiTamás Korcsmáros
Aug 8, 2013·The Journal of Clinical Investigation·Anju SinghShyam Biswal
Aug 15, 2013·Molecular Cancer Therapeutics·Tracy Murray-StewartRobert A Casero
Sep 14, 2013·Oncotarget·Niraj M ShahDavid J MacEwan
May 6, 2014·Molecular Therapy : the Journal of the American Society of Gene Therapy·Maria Angelica CortezJames W Welsh
Dec 31, 2014·Genetics Research International·Alessia CartaDuncan Ayers
Jan 6, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Liang ShiFang Zheng
Apr 22, 2015·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Liang ShiXiangyang Lin
Jun 30, 2015·Free Radical Biology & Medicine·Shohei Murakami, Hozumi Motohashi
Jul 15, 2015·Free Radical Biology & Medicine·Katja M KanninenAnna-Liisa Levonen
Aug 11, 2015·Analytical Cellular Pathology (Amsterdam)·Alfred Buhagiar, Duncan Ayers

❮ Previous
Next ❯

Citations

Dec 18, 2015·Dalton Transactions : an International Journal of Inorganic Chemistry·U K KomarnickaA Kyzioł
Apr 2, 2016·Free Radical Biology & Medicine·Shelly C LuSantiago Lamas
Apr 27, 2016·Expert Opinion on Drug Metabolism & Toxicology·Kyle McIntoshAmit K Tiwari
Mar 10, 2017·Genes·Duncan Ayers, Jo Vandesompele
Dec 17, 2015·Mass Spectrometry Reviews·Gerben Menschaert, David Fenyö
Sep 2, 2017·International Journal of Molecular Sciences·Christine Sturm, Anika E Wagner
Dec 12, 2018·Cellular and Molecular Life Sciences : CMLS·Yann GuéguenTeni G Ebrahimian
Jun 12, 2017·Biochemistry. Biokhimii︠a︡·N K ZenkovE B Menshchikova
Nov 16, 2017·Oxidative Medicine and Cellular Longevity·Rocco CaggianoRaffaella Faraonio
May 18, 2019·Oxidative Medicine and Cellular Longevity·Emiliano Panieri, Luciano Saso
Mar 21, 2019·Frontiers in Pharmacology·Lei LiuSylvain Doré
Nov 14, 2019·Cancers·Alina-Andreea ZimtaIoana Berindan-Neagoe
Apr 13, 2018·Oxidative Medicine and Cellular Longevity·F P FabrizioL A Muscarella
May 16, 2020·Oxidative Medicine and Cellular Longevity·Can LuChen Chen
Jan 4, 2021·Molecular Biology Reports·Tapan BehlSimona Bungau
Dec 11, 2020·Oxidative Medicine and Cellular Longevity·Visweswara Rao PasupuletiMohammad Saffree Jeffree
Aug 18, 2020·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Yin-Hwa ShihTzong-Ming Shieh

❮ Previous
Next ❯

Methods Mentioned

BETA
ubiquitination
immunoprecipitation
ChIP-Seq
transfection
biopsy

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology
Ren-Qiang MaXiao-yi Duan
Journal of Oncology
Masahiro MizoguchiTomio Sasaki
Analytical Cellular Pathology (Amsterdam)
Alfred Buhagiar, Duncan Ayers
© 2021 Meta ULC. All rights reserved