miRNA-Mediated Regulation of Adult Hippocampal Neurogenesis; Implications for Epilepsy

Brain Plasticity
Pascal BielefeldCarlos P Fitzsimons

Abstract

Hippocampal neural stem/progenitor cells (NSPCs) proliferate and differentiate to generate new neurons across the life span of most mammals, including humans. This process takes place within a characteristic local microenvironment where NSPCs interact with a variety of other cell types and encounter systemic regulatory factors. Within this microenvironment, cell intrinsic gene expression programs are modulated by cell extrinsic signals through complex interactions, in many cases involving short non-coding RNA molecules, such as miRNAs. Here we review the regulation of gene expression in NSPCs by miRNAs and its possible implications for epilepsy, which has been linked to alterations in adult hippocampal neurogenesis.

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Citations

Jun 18, 2020·Nature Reviews. Neurology·Gary P Brennan, David C Henshall
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Apr 8, 2021·The British Journal of Nutrition·Umit OzorhanSoner Dogan
Sep 12, 2020·CNS & Neurological Disorders Drug Targets·Shareen SinghAshish Kumar Rehni

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Methods Mentioned

BETA
acetylation
chemical modification
single cell sequencing

Software Mentioned

EpimiRBase

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