miRNA-Processing Gene Methylation and Cancer Risk

Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
Brian T JoyceLifang Hou

Abstract

Background: Dysregulation of miRNA and methylation levels are epigenetic hallmarks of cancer, potentially linked via miRNA-processing genes. Studies have found genetic alterations to miRNA-processing genes in cancer cells and human population studies. Our objective was to prospectively examine changes in DNA methylation of miRNA-processing genes and their associations with cancer risk.Methods: We examined cohort data from the Department of Veterans' Affairs Normative Aging Study. Participants were assessed every 3 to 5 years starting in 1999 through 2013 including questionnaires, medical record review, and blood collection. Blood from 686 consenting participants was analyzed using the Illumina 450K BeadChip array to measure methylation at CpG sites throughout the genome. We selected 19 genes based on a literature review, with 519 corresponding CpG sites. We then used Cox proportional hazards models to examine associations with cancer incidence, and generalized estimating equations to examine associations with cancer prevalence. Associations at false discovery rate < 0.05 were considered statistically significant.Results: Methylation of three CpGs (DROSHA: cg23230564, TNRC6B: cg06751583, and TNRC6B: cg21034183) was prospectively...Continue Reading

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Citations

Sep 28, 2018·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Lory SantarelliMassimo Bovenzi
Dec 17, 2020·Cell Biology International·Sunmathy KanakamaniThejaswini Venkatesh
Jan 3, 2021·Cellular Signalling·Neda YaghoubiSeyed Hamid Aghaee-Bakhtiari
Jan 7, 2021·Nucleic Acids Research·Paulina Galka-MarciniakPiotr Kozlowski
Jun 5, 2020·Ageing Research Reviews·Ekaterina ProshkinaAlexey Moskalev
Apr 29, 2021·Seminars in Cancer Biology·Anup S PathaniaKishore B Challagundla

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