miRNA profiling in colorectal cancer highlights miR-1 involvement in MET-dependent proliferation

Molecular Cancer Research : MCR
James F ReidMarco A Pierotti

Abstract

Altered expression of miRNAs is associated with development and progression of various human cancers by regulating the translation of oncogenes and tumor suppressor genes. In colorectal cancer, these regulators complement the Vogelstein multistep model of pathogenesis and have the potential of becoming a novel class of tumor biomarkers and therapeutic targets. Using quantitative real-time PCR, we measured the expression of 621 mature miRNAs in 40 colorectal cancers and their paired normal tissues and identified 23 significantly deregulated miRNAs. We subsequently evaluated their association with clinical characteristics of the samples and presence of alterations in the molecular markers of colorectal cancer progression. Expression levels of miR-31 were correlated with CA19-9 and miR-18a, miR-21, and miR-31 were associated with mutations in APC gene. To investigate the downstream regulation of the differentially expressed miRNAs identified, we integrated putative mRNA target predictions with the results of a meta-analysis of seven public gene expression datasets of normal and tumor samples of colorectal cancer patients. Many of the colorectal cancer deregulated miRNAs computationally mapped to targets involved in pathways relate...Continue Reading

References

Jun 1, 1990·Cell·E R Fearon, B Vogelstein
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Feb 20, 2004·Proceedings of the National Academy of Sciences of the United States of America·George Adrian CalinCarlo M Croce
Oct 25, 2006·Nature Reviews. Cancer·George A Calin, Carlo M Croce
Jan 31, 2008·JAMA : the Journal of the American Medical Association·Aaron J SchetterCurtis C Harris
Dec 17, 2008·Cancer Research·Cristina MiglioreSilvia Giordano
Jan 31, 2009·The American Journal of Pathology·Geoffrey ChildsNicolas F Schlecht
Jun 16, 2009·Cell·Scott ValastyanRobert A Weinberg
Aug 13, 2009·Genes, Chromosomes & Cancer·James F ReidMarco A Pierotti
Aug 28, 2009·The Journal of Biological Chemistry·Dongsheng YanLili Tu
Dec 31, 2009·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Zhenfeng DuanFrancis J Hornicek
Feb 6, 2010·Journal of Digestive Diseases·Ying Xin WangHeng Jun Gao
May 18, 2010·International Journal of Cancer. Journal International Du Cancer·Ming LiuFeng Bi
Nov 26, 2010·Nature Reviews. Molecular Cell Biology·Livio TrusolinoPaolo M Comoglio
Jan 15, 2011·Cell Death and Differentiation·E A AfanasyevaF Westermann
Feb 26, 2011·International Journal of Cancer. Journal International Du Cancer·Jacques FerlayDonald Maxwell Parkin

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Citations

Nov 19, 2013·PloS One·Shiori FurukawaTetsu Akiyama
Sep 6, 2013·International Journal of Molecular Sciences·Juan Carlos Samamé Pérez-VargasFilippo Pietrantonio
Apr 20, 2013·World Journal of Gastroenterology : WJG·Kai SunGuo-Xin Li
Apr 26, 2014·World Journal of Gastroenterology : WJG·Jing-Jia Ye, Jiang Cao
Nov 20, 2013·Nature Reviews. Endocrinology·Pierlorenzo PallanteAlfredo Fusco
May 28, 2015·Journal of Cellular Physiology·Viktorija SokolovaMarco A Pierotti
Oct 29, 2015·Journal of Cellular and Molecular Medicine·Xin Yu, Zheng Li
Apr 16, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Chao HanQuancheng Kan
Mar 11, 2016·Clinical and Translational Gastroenterology·Daniel F PellattMartha L Slattery
Feb 7, 2014·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Zhenfeng DuanFrancis Hornicek
Sep 13, 2015·Drug Development Research·Zeynep F KaragonlarNeşe Atabey
Dec 3, 2014·Translational Research : the Journal of Laboratory and Clinical Medicine·Sanaa EissaHanan H Shehata
Jul 29, 2015·Annals of Surgical Oncology·Derek J ErstadJames C Cusack
Dec 9, 2014·International Journal of Cancer. Journal International Du Cancer·Martha L SlatteryRoger K Wolff
Nov 22, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Youwei KouQiang Wang
Oct 31, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Jie ChaiHongliang Guo
Aug 21, 2012·Molecular Oncology·Hiromu SuzukiMasahiro Kai
Jun 21, 2014·BioMed Research International·Chao HanQuancheng Kan
Dec 3, 2014·Biochimica Et Biophysica Acta·Stine Aske DanielsenRagnhild A Lothe
Feb 6, 2015·TheScientificWorldJournal·Panchalee BhaumikRituraj Purohit
Jun 12, 2016·Critical Reviews in Oncology/hematology·Martin WeissMatthias B Stope
Apr 9, 2015·PloS One·Jonathan RiceSusan Galandiuk
Aug 7, 2016·Evidence-based Complementary and Alternative Medicine : ECAM·Meiyu PiaoBangmao Wang
Jul 30, 2016·Cancer Letters·Rajbir SinghArnab Chakravarti
Jun 30, 2016·Endocrine-related Cancer·Helen C MillerAndrea Frilling
May 2, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Elmira Safaie QamsariMehdi Yousefi
Jan 10, 2018·Veterinary and Comparative Oncology·Y-C LaiN Miura
Aug 31, 2017·American Journal of Respiratory and Critical Care Medicine·Asawari KordeShervin S Takyar
Mar 17, 2019·Bioscience Reports·Zhaoli ZhangJinlong Li
May 28, 2019·Journal of Cellular Physiology·Alireza AnvarniaDariush Shanehbandi

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