miRNA-Regulated Key Components of Cytokine Signaling Pathways and Inflammation in Rheumatoid Arthritis

Medicinal Research Reviews
Ashish Ranjan SharmaChiranjib Chakraborty

Abstract

Rheumatoid arthritis (RA) is an inflammatory disease that primarily affects joints. This autoimmune disease pathogenesis is related to cytokine signaling. In this review, we have described the existence of various microRNAs (miRNAs) involved in regulation of major protein cascades of cytokine signaling associated with RA. Moreover, we have tried to portray the role of various miRNAs in different cytokines such as TNF-α, IL-1, IL-6, IL-10, IL-17, IL-18, IL-21, and granulocyte macrophage colony-stimulating factor (GMCSF). Along with this, we have also discussed the miRNA regulation in T cells and synovial tissue. From the analyzed data, we suggest that miR-146a and miR-155 might be the potential therapeutic target for treating RA. The insight illustrated in this review will offer a better understanding of the role of miRNA in cytokine signaling pathways and inflammation during RA and could project them as diagnostic or therapeutic agents in near future.

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Citations

Jul 19, 2019·Journal of Cellular Biochemistry·Bidyut MallickChiranjib Chakraborty
Sep 6, 2019·Journal of Cellular Physiology·Nicola MaruottiFrancesco Paolo Cantatore
Oct 8, 2019·Epigenetics : Official Journal of the DNA Methylation Society·Xiaowei ZhuShufeng Lei
May 8, 2020·Cell Biology International·Chiranjib ChakrabortyGovindasamy Agoramoorthy
Aug 1, 2019·Experimental and Therapeutic Medicine·Yan ChenChunyan Qian
Feb 13, 2020·Frontiers in Immunology·Jinghua WangZengyan Wang
Dec 5, 2017·Mediators of Inflammation·Federico BiscettiGianfranco Ferraccioli
Nov 21, 2018·In Vitro Cellular & Developmental Biology. Animal·Zunzhong LiXingfu Li
Dec 29, 2020·Journal of Advanced Research·Chiranjib ChakrabortySang-Soo Lee
Jul 22, 2017·International Immunopharmacology·Hong-Ju ZhangXiu-Hua Wang
Apr 30, 2020·Molecular Therapy. Nucleic Acids·Chiranjib ChakrabortySang-Soo Lee
May 25, 2021·Frontiers in Immunology·Salar PashangzadehNazanin Mojtabavi

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